与B细胞非霍奇金淋巴瘤相关的丙型肝炎病毒：临床上以及治疗上的挑战

Title:Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges

Volume: 18 Issue: 7

关键词: 丙型肝炎病毒，B细胞非霍奇金淋巴瘤，淋巴瘤，淋巴增生， 混合型冷球蛋白血症，血管炎

摘要: Hepatitis C virus (HCV) is a major cause of liver-related morbidity and is strongly associated with B-cell lymphoproliferative disorders. Data from epidemiological, biological and clinical investigations support the hypothesis of a pathogenetic role of HCV in at least a subgroup of patients with B-cell non-Hodgkin’s lymphoma (B-NHL). Morphologically, HCV-associated B-NHL represents a variety of histological subtypes. The comprehension of the mechanisms of HCV persistence and of its role in the lymphomagenesis will be useful to set new strategies with the aim to prevent and treat HCV-associated B-NHLs. This hypothesis of a virus-induced mechanism of lymphomagenesis arises from the growing evidence that successful antiviral treatment is often linked to regression of some types of HCV-related indolent B-NHLs.

Cite this article as:

Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges, Current Drug Targets 2017; 18 (7) . https://dx.doi.org/10.2174/1389450117666160201112525