摘要
需要器官移植的患者经常经受不同的皮肤病,需要进行免疫抑制治疗。具体的皮肤副作用比如痤疮、多毛症或其他毛囊皮脂腺紊乱、牙龈增生、紫癜或毛细管扩张通常与免疫抑制介导有关。大部分情况是温和的,但是可能会影响患者的审美是生命的质量并且减少了治疗的依附性。此外,器官移植受体经常会受到皮肤感染,间接导致免疫抑制。疱疹病毒的再激活通常是移植后几个月,然而党减少免疫抑制之后,皮肤感染主要由人乳头状瘤宾度感染并且表现出局限性。很少有细菌感染。长期的免疫抑制治疗主要体现在肿瘤早期和皮肤癌的发展,这有一定的风险使得时间延长和对病人的存活有明显的影响。本文对近几年的文献报道的数据对该主题进行综述,为了了解器官移植受体患者与使用免疫抑制药物相关的主要皮肤紊乱的特征,包括其风险、流行病学、临床表现与管理方面的知识。
关键词: 皮肤,副作用,免疫抑制治疗,器官移植
Current Drug Targets
Title:Characterization and Management of Cutaneous Side Effects Related to the Immunosuppressive Treatment in Solid Organ Recipients
Volume: 18 Issue: 4
关键词: 皮肤,副作用,免疫抑制治疗,器官移植
摘要: Patients who underwent solid organ transplantation frequently suffer from different skin diseases, as consequence of the immunosuppressive treatment. Specific cutaneous side effects such as acne, hypertricosis or other pilosebaceous unit disorders, gingival hyperplasia, purpura or teleangiectasies are commonly associated to immunosuppressive medications. The majority of these conditions are benign, but the aesthetic concern may affect the patient is quality of life and reduce the adherence to the therapy. Moreover, solid organ transplant recipients frequently develop skin infections, as an indirect consequence of the immunosuppressive regimens. Herpes virus reactivation is more common few months after transplantation, whereas when the immunosuppression is reduced, the skin infections are mainly represented by human papilloma virus infections and localized mycosis. Bacterial infections are relatively rare. Long-term consequences of the immunosuppressive therapy are represented by development of precancerosis and skin cancers, with a risk that enhances over the time and a significant impact on patient survival. The aim of this paper is to provide an overview of the data published in the recent literature about this topic, in order to characterize the main skin disorders associated to the use of immunosuppressive drugs in solid organ recipients, giving information about their risk, epidemiology, clinical manifestations and management.
Export Options
About this article
Cite this article as:
Characterization and Management of Cutaneous Side Effects Related to the Immunosuppressive Treatment in Solid Organ Recipients, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666160112115524
DOI https://dx.doi.org/10.2174/1389450117666160112115524 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response and/or therapy ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease
Current Medicinal Chemistry Chromosome 9 Inversion: Pathogenic or Benign? A Comprehensive Systematic Review of all Clinical Reports
Current Molecular Medicine Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease
Current Alzheimer Research Nanobulges: A Duplex Nanosystem for Multidimensional Applications
Current Nanoscience Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
Current Genomics Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina
Current Diabetes Reviews Targeted Therapy for Brain Tumours: Role of PARP Inhibitors
Current Cancer Drug Targets CT Findings of Pulmonary Metastases from Primary Cardiac Angiosarcoma
Current Medical Imaging Secoiridoid Amarogentin from ‘Gentianaceae’ with their Health Promotion, Disease Prevention and Modern Analytical Aspects
Current Bioactive Compounds Molecular Probing and Imaging of Histone Deacetylase Inhibitors in Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis
Current Drug Targets ANN-QSAR Model for Virtual Screening of Androstenedione C-Skeleton Containing Phytomolecules and Analogues for Cytotoxic Activity Against Human Breast Cancer Cell Line MCF-7
Combinatorial Chemistry & High Throughput Screening Modelling DNA Repair Pathways: Recent Advances and Future Directions
Current Pharmaceutical Design MRI of Focal Liver Lesions
Current Medical Imaging The Emerging Role of TRP Channels in Mechanisms of Temperature and Pain Sensation
Current Neuropharmacology Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism
Current Drug Metabolism Peptides Targeting Toll-Like Receptor Signalling Pathways for Novel Immune Therapeutics
Current Pharmaceutical Design Revisiting Non-Cancer Drugs for Cancer Therapy
Current Topics in Medicinal Chemistry Identification and Targeting of Tumor Escape Mechanisms: A New Hope for Cancer Therapy?
Current Pharmaceutical Design Titanocene Y - Transport and Targeting of an Anticancer Drug Candidate
Letters in Drug Design & Discovery