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摘要
多酚是含有酚单元的天然和合成有机化学品的一类结构。许多流行病学,临床前和临床研究强烈支持其对人类的健康有益。多酚类包括完全不同的复杂性等级的分子,从简单分子到高度聚合的结构。它们分为:酚酸,黄酮类,木脂素和不太常见的对称二苯代乙烯。这项工作首先是为了概括目前在分类,化学成分和多酚代谢方面的研究。然后,我们报道了多酚的癌症预防和治疗效果,特别是绿茶多酚(GTP)(-)-表没食子儿茶素-3-没食子酸酯(EGCG)。多酚如EGCG及其合成类似物通过调节和调节多种信号转导途径和转录因子,膜相关受体酪氨酸激酶(RTK),脂肪酸代谢和脂筏或甲基化与其它新出现的靶标例如蛋白酶体、端粒酶和癌症干细胞干扰癌症形成。在这里,我们概括了几种潜在的多酚(主要是EGCG和EGCG类似物)的分子靶点及其在不同人类癌细胞和动物模型中的抗癌作用,我们对进行研究的GTP抗肿瘤性质还列出了临床试验阶段I和阶段II。
关键词: 临床试验
Current Drug Targets
Title:Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents
Volume: 18 Issue: 2
关键词: 临床试验
摘要: Polyphenols are a structural class of natural and synthetic organic chemicals which contain phenol units. Numerous epidemiological, preclinical and clinical studies have strongly supported their benefical effects for human health. Polyphenols group include molecules of utterly different complexity grades, ranging from simple molecules to highly polymerized structures. They are classified into: Phenolic acids, Flavonoids, Lignans and the less common Stilbenes. This work first intends to review the current studies on classification, chemical composition and metabolism of polyphenols. Then, we have reported cancer preventive and treatment effects of polyphenols, especially focused in the green tea polyphenol (GTP) (-)-Epigallocatechin-3-gallate (EGCG). Polyphenols such as EGCG and their synthetic analogs interfere in carcinogenesis by modulating and regulating multiple signaling pathways and transcription factors, membrane-associated receptor tyrosine kinases (RTKs), fatty acid metabolism and lipid rafts or methylation together with other emerging targets such as proteasome, telomerase and cancer stem cells. Here, we have reviewed several potential molecular targets of polyphenols (mainly EGCG and EGCG analogs) and their anticancer effects in cellular and animal models of different human carcinomas and we have also listed Phases I and II clinical trials conducted to study the antitumor properties of GTPs.
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Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents, Current Drug Targets 2017; 18 (2) . https://dx.doi.org/10.2174/1389450117666160112113930
DOI https://dx.doi.org/10.2174/1389450117666160112113930 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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