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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Beta-Blockers: Current State of Knowledge and Perspectives

Author(s): Magdalena Ogrodowczyk, Katarzyna Dettlaff and Anna Jelinska

Volume 16, Issue 1, 2016

Page: [40 - 54] Pages: 15

DOI: 10.2174/1389557515666151016125948

Price: $65


It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with betablocking properties which could extend their therapeutic potential.

Keywords: Activity, application, aryloxyaminopropanol derivatives, beta-blockers, structure.

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