Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder which is characterized by motor neuron (MN) dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs) can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.
Keywords: Amyotrophic lateral sclerosis, mesenchymal stem cells, stem cell, treatment.
Current Stem Cell Research & Therapy
Title:Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis
Volume: 11 Issue: 1
Author(s): Mahsa Hajivalili, Fatemeh Pourgholi, Hossein Samadi Kafil, Farhad Jadidi-Niaragh and Mehdi Yousefi
Affiliation:
Keywords: Amyotrophic lateral sclerosis, mesenchymal stem cells, stem cell, treatment.
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder which is characterized by motor neuron (MN) dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs) can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.
Export Options
About this article
Cite this article as:
Hajivalili Mahsa, Pourgholi Fatemeh, Kafil Samadi Hossein, Jadidi-Niaragh Farhad and Yousefi Mehdi, Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis, Current Stem Cell Research & Therapy 2016; 11 (1) . https://dx.doi.org/10.2174/1574888X10666150902095031
DOI https://dx.doi.org/10.2174/1574888X10666150902095031 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector
Current Pharmaceutical Design Antioxidant Enzyme Mimics with Synergism
Mini-Reviews in Medicinal Chemistry Vascular Endothelial Growth Factor Electro-Gene Therapy Improves Functional Outcome in a Mouse Model of ALS
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Meet Our Editorial Board Member
Current Alzheimer Research Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders
CNS & Neurological Disorders - Drug Targets In the Rush for Green Gold: Can Green Tea Delay Age-Progressive Brain Neurodegeneration?
Recent Patents on CNS Drug Discovery (Discontinued) Cell Culture Models of Oxidative Stress and Injury in the Central Nervous System
Current Neurovascular Research Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
Current Neuropharmacology Histone Deacetylase Inhibitors: Therapeutic Agents and Research Tools for Deciphering Motor Neuron Diseases
Current Medicinal Chemistry Nitric Oxide-Derived Oxidants with a Focus on Peroxynitrite: Molecular Targets,Cellular Responses and Therapeutic Implications
Current Pharmaceutical Design Emerging Roles of the Neurotrophic Peptides IGF-1 and PACAP in Amyotrophic Lateral Sclerosis
Current Protein & Peptide Science Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection
Current HIV Research Editorial (Thematic Selection: Mitochondrial Dysfunction & Neurological Disorders)
Current Neuropharmacology Complex and Differential Glial Responses in Alzheimer´s Disease and Ageing
Current Alzheimer Research Targeting Mitochondrial Dysfunction in Chronic Heart Failure: Current Evidence and Potential Approaches
Current Pharmaceutical Design Molecular and Cellular Control of Dendrite Maturation During Brain Development
Current Molecular Pharmacology Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders
Current Drug Targets Selegiline (l-Deprenyl) as a Unique Neuroprotective Agent for Chronic Neurodegenerative Disorders- A Lesson from MAO Inhibition
Current Medicinal Chemistry - Central Nervous System Agents Editorial [Hot Topic: Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands (Executive Guest Editor: Carmen Abate )]
Current Pharmaceutical Design