摘要
传递生物活性物质的结肠靶向脂质体系统(CTLS)对结肠疾病的治疗效果显著。使用多种药物给药系统的结肠靶向的方法已经被采用,但本文第一次提及了结肠靶向脂质体系统(CTLS)。虽然脂质体不适用于结肠靶向口服途径,但本文明确提出了利用可利用的配体如多肽或蛋白质(如RGD、NgR、纤连蛋白模拟肽和与转铁蛋白等)、唾液酸化Lewis X(SLX)、低分子量配体如叶酸、单克隆抗体、内皮抑素基因和硫脂等结肠靶向脂质体系统(CTLS)的研究进展。此外,本文提出了使用放射性元素铼[188Re]、锝[99mTc]和铟[111In]的结肠靶向脂质体系统(CTLS)诊断(或影像)潜力。基于从事结肠靶向脂质体用于治疗诊断学的设计与开发的研究人员的研究进展,本文对相关纳米技术进行了总结。
关键词: 脂质体,结肠癌,靶向治疗,诊断,放射性标记。
Current Molecular Medicine
Title:Colon Targeted Liposomal Systems (CTLS): Theranostic Potential
Volume: 15 Issue: 7
Author(s): A. Jain and S.K. Jain
Affiliation:
关键词: 脂质体,结肠癌,靶向治疗,诊断,放射性标记。
摘要: Colon targeted liposomal systems (CTLS) for the delivery of bioactives have been well addressed in therapeutic manifestations of colonic ailments. Number of approaches using various drug delivery systems for colon targeting has been worked out but CTLS are first time being lime lighted in this review. Although liposomes are not supposed to be suitable for colon targeting via oral route this review explicitly provides advances of CTLS using exploitable ligands such as peptides or proteins (e.g. RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc. Moreover, it is bringing forth the diagnostic (or imaging) potential of CTLS using 188Re, 99mTc, and 111In, etc. This review presents nanotechnology based advances for liposome researchers engaged in design and development of colon targeted liposomes for theranostic exploration.
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Cite this article as:
A. Jain and S.K. Jain , Colon Targeted Liposomal Systems (CTLS): Theranostic Potential, Current Molecular Medicine 2015; 15 (7) . https://dx.doi.org/10.2174/1566524015666150831131320
DOI https://dx.doi.org/10.2174/1566524015666150831131320 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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