摘要
因为其表达受到限制,CD6已被利用作为药物的靶点,与T细胞相比,它有一个特征的细胞表面配体和CD166,并且它能通过激活长胞质尾调节T细胞。CD6可以分别以消极和积极的方式影响的启动和维持T细胞的功能,是了解一个潜在的药物靶标这些双重影响的重要,因此,了解潜在药物靶标的双重影响十分重要。单克隆抗体的临床作用模式(单克隆抗体)能识别CD6等细胞表面的受体,它是一种常用的细胞毒性衰竭 。 目前还不能确定当前的治疗策略如何以CD6扰动函数 为靶点。随着新结构数据的出现,本文提供了一个批判性的分析和对各种进行测试实验的药物进行了解释并就如何更有效地开发药物提供了一些建议。
关键词: CD6,CD166, SLP-76,T细胞激活,抑制,免疫,信号转导
Current Drug Targets
Title:CD6 as a Cell Surface Receptor and As a Target for Regulating Immune Responses
Volume: 17 Issue: 6
Author(s): Marion H. Brown
Affiliation:
关键词: CD6,CD166, SLP-76,T细胞激活,抑制,免疫,信号转导
摘要: CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long cytoplasmic tail. CD6 can affect both the initiation and maintenance of T cell function in a negative and positive manner respectively so that it is important to understand these dual effects of a potential drug target. The effective mode of action of clinical monoclonal antibodies (mAbs) that recognise cell surface receptors including CD6 is commonly cytotoxic depletion of cells. It is not clear how current therapeutic strategies to target CD6 perturb function. With the benefit of new structural data, this review provides a critical analysis and interpretation of experiments in which various reagents have been tested and offers some suggestions as how more effective drugs may be developed.
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Cite this article as:
Marion H. Brown , CD6 as a Cell Surface Receptor and As a Target for Regulating Immune Responses, Current Drug Targets 2016; 17 (6) . https://dx.doi.org/10.2174/1389450116666150825120536
DOI https://dx.doi.org/10.2174/1389450116666150825120536 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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