摘要
多年来,Polo样激酶1(Plk1)作为治疗靶点已经获得巨大的效益。Plk1是高度保守的丝氨酸/苏氨酸激酶之一,在真核细胞有丝分裂,细胞分裂和DNA损伤反应起着关键作用。本文总结了Plk1在细胞周期的功能、其在治疗儿童癌症方面的作用和作为预后因素的价值。此外,本文介绍了药物抑制的研究进展以及以Plk1为靶点的小分子药物治疗癌症的化疗方法的发展。最后,对PLK1抑制剂的临床试验进行了简要回顾。
关键词: 化疗,抑制剂,小儿肿瘤,PLK1,化疗,抑制剂,小儿肿瘤,PLK1,放疗,治疗。
Current Drug Targets
Title:PLK1 Inhibition: Prospective Role for the Treatment of Pediatric Tumors
Volume: 17 Issue: 14
Author(s): Julia Alejandra Pezuk, Elvis Terci Valera, María Sol Brassesco
Affiliation:
关键词: 化疗,抑制剂,小儿肿瘤,PLK1,化疗,抑制剂,小儿肿瘤,PLK1,放疗,治疗。
摘要: Over the years, polo-like kinase 1 (PLK1) has garnered great interest as a therapeutic target. The PLK1 is a member of a highly conserved serine/threonine kinase family that plays pivotal roles in mitosis, cytokinesis and DNA damage response in eukaryotic cells. In this review, we summarize the functions of PLK1 during cell cycle progression, its roles in human pediatric cancer and its value as a prognostic factor. Furthermore, we introduce the advances in pharmacological inhibition and the newly chemotherapeutic development of small-molecules to target PLK1 in cancer treatment. Finally, clinical trials with PLK1 inhibitors are briefly reviewed.
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Julia Alejandra Pezuk, Elvis Terci Valera, María Sol Brassesco , PLK1 Inhibition: Prospective Role for the Treatment of Pediatric Tumors, Current Drug Targets 2016; 17 (14) . https://dx.doi.org/10.2174/1389450116666150825120235
DOI https://dx.doi.org/10.2174/1389450116666150825120235 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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