Abstract
Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.
Keywords: Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.
Current Organic Synthesis
Title:Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3
Volume: 12 Issue: 5
Author(s): Ronaldo Aloise Pilli, Luiz Fernando Toneto Novaes, Vânia Maria Teixeira Carneiro, Roberta Lopes Drekener and Carolina Martins Avila
Affiliation:
Keywords: Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.
Abstract: Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.
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Pilli Aloise Ronaldo, Toneto Novaes Fernando Luiz, Teixeira Carneiro Maria Vânia, Drekener Lopes Roberta and Avila Martins Carolina, Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3, Current Organic Synthesis 2015; 12 (5) . https://dx.doi.org/10.2174/157017941205150821121851
DOI https://dx.doi.org/10.2174/157017941205150821121851 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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