Abstract
This study investigated the influence of Vitamin C (Vit C) on Adriamycin-induced hypercholesterolemia and body weight in rats.
Sixty-four male Albino Wistar rats were divided into eight groups : Control (CO), Adriamycin (ADR), three groups received different doses of Vit C and three groups received Adriamycin plus different doses of Vitamin C (ADR +Vit C).
ADR treated rats showed an insignificant increase in serum cholesterol levels compared with the control group (animals). ADR+Vit C groups showed a significant increase of serum cholesterol level compared to the control group. Meanwhile, body weight in ADR treated rats decreased compared with the control group but this reduction was not significant). Body weight in ADR+Vit C groups demonstrated a significant decrease compared to the control animals.
Conclusion: Findings of the current study imply that treatment with different doses of Vitamin C have possibly deleterious effects on Adriamycin-induced hypercholesterolemia as a dose dependent manner and body weight in rat.
Keywords: Adriamycin, vitamin c, hypercholesterolemia.
Current Nutrition & Food Science
Title:The Effects of Vitamin C on Adriamycin-Induced Hypercholesterolemia in Rat
Volume: 11 Issue: 4
Author(s): Reza Mohebbati, Abolfazl K. Rad, Mohammad N. Shafei, Mohammad Soukhtanloo, Sara Hosseinian, Farimah Beheshti and Mohammad R. Khazdair
Affiliation:
Keywords: Adriamycin, vitamin c, hypercholesterolemia.
Abstract: This study investigated the influence of Vitamin C (Vit C) on Adriamycin-induced hypercholesterolemia and body weight in rats.
Sixty-four male Albino Wistar rats were divided into eight groups : Control (CO), Adriamycin (ADR), three groups received different doses of Vit C and three groups received Adriamycin plus different doses of Vitamin C (ADR +Vit C).
ADR treated rats showed an insignificant increase in serum cholesterol levels compared with the control group (animals). ADR+Vit C groups showed a significant increase of serum cholesterol level compared to the control group. Meanwhile, body weight in ADR treated rats decreased compared with the control group but this reduction was not significant). Body weight in ADR+Vit C groups demonstrated a significant decrease compared to the control animals.
Conclusion: Findings of the current study imply that treatment with different doses of Vitamin C have possibly deleterious effects on Adriamycin-induced hypercholesterolemia as a dose dependent manner and body weight in rat.
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Cite this article as:
Mohebbati Reza, Rad K. Abolfazl, Shafei N. Mohammad, Soukhtanloo Mohammad, Hosseinian Sara, Beheshti Farimah and Khazdair R. Mohammad, The Effects of Vitamin C on Adriamycin-Induced Hypercholesterolemia in Rat, Current Nutrition & Food Science 2015; 11 (4) . https://dx.doi.org/10.2174/1573401311666150729230335
DOI https://dx.doi.org/10.2174/1573401311666150729230335 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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