Abstract
Since the discovery of liposomes, the drug delivery technology has made a tremendous advancement in the field of medicine. Owing to their biocompatibility, efficacy, targeting ability and improved in vivo performance, liposomes has become popular as versatile drug carrier systems. Controlled and sustained drug release, lowered systemic toxicity and improved pharmacokinetic and pharmacodynamic properties of drug are the potential applications of liposomal drug delivery. Drugs encapsulated in liposomes can be targeted actively and passively to the tumor specific site with improved efficacy and reduced off-target effects. Development of multifunctional liposomes for targeting cell organelles, long acting (PEGylated) and with combination of drugs is a hot-topic of current research. In recent years, the focus of liposomal technology has been on the combined applications of diagnostics and therapeutics. The present work reviews the liposomal drug delivery field, summarizes the success of liposomal technology in translation from concept to clinical acceptance and recent developments in the delivery of anti-fungal, antibiotic, anti-inflammatory and anti-cancer drugs.
Keywords: Liposomes, immunoliposomes, proteins and peptides, vaccines, gene delivery, active targeting.
Pharmaceutical Nanotechnology
Title:Recent Advances in Liposomal Drug Delivery: A Review
Volume: 3 Issue: 1
Author(s): Vijaykumar Nekkanti and Sandeep Kalepu
Affiliation:
Keywords: Liposomes, immunoliposomes, proteins and peptides, vaccines, gene delivery, active targeting.
Abstract: Since the discovery of liposomes, the drug delivery technology has made a tremendous advancement in the field of medicine. Owing to their biocompatibility, efficacy, targeting ability and improved in vivo performance, liposomes has become popular as versatile drug carrier systems. Controlled and sustained drug release, lowered systemic toxicity and improved pharmacokinetic and pharmacodynamic properties of drug are the potential applications of liposomal drug delivery. Drugs encapsulated in liposomes can be targeted actively and passively to the tumor specific site with improved efficacy and reduced off-target effects. Development of multifunctional liposomes for targeting cell organelles, long acting (PEGylated) and with combination of drugs is a hot-topic of current research. In recent years, the focus of liposomal technology has been on the combined applications of diagnostics and therapeutics. The present work reviews the liposomal drug delivery field, summarizes the success of liposomal technology in translation from concept to clinical acceptance and recent developments in the delivery of anti-fungal, antibiotic, anti-inflammatory and anti-cancer drugs.
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Cite this article as:
Nekkanti Vijaykumar and Kalepu Sandeep, Recent Advances in Liposomal Drug Delivery: A Review, Pharmaceutical Nanotechnology 2015; 3 (1) . https://dx.doi.org/10.2174/2211738503666150709173905
DOI https://dx.doi.org/10.2174/2211738503666150709173905 |
Print ISSN 2211-7385 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-7393 |
Call for Papers in Thematic Issues
Polymeric nanocarriers in drug delivery
Polymeric nanocarriers play a crucial role in drug delivery due to their versatility, and unique properties for targeting and modifying drug release. Their ability to enhance therapeutic outcomes, reduce side effects, and enable the delivery of drugs in a more targeted and controlled manner made them popular in the last ...read more
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