Abstract
Pulmonary complications associated with autoimmune connective tissue disease (CTD) are common causes of clinical interstitial lung disease (ILD). Pleural manifestations are dominated by inflammation and varying amounts of diffuse fibrosis. In the lung, a wide spectrum of histologic injury patterns are encountered in every anatomic location including small airway disease most commonly in the form of chronic bronchiolitis, vascular changes, and interstitial lung disease ranging from diffuse alveolar damage to advanced pulmonary fibrosis. The most common interstitial pattern, seen in nearly all of the different CTDs, is a cellular and variably fibrotic ILD referred to as nonspecific interstitial pneumonia (NSIP). Each of the major CTDs has particular manifestations more commonly manifested, but the histopathologic changes found in these CTDs are often not specific and a definitive diagnosis usually requires detailed clinical, serologic, and pathologic correlation as well as close patient follow-up.
Keywords: Interstitial lung disease, mixed connective tissue disease, rheumatic lung disease, rheumatoid lung, scleroderma, Sjogren syndrome, systemic lupus erythematosus.
Current Respiratory Medicine Reviews
Title:Histopathology of Connective Tissue Disease-Associated Pleuropulmonary Disease
Volume: 11 Issue: 2
Author(s): Maxwell Smith, Brandon Larsen, Henry Tazelaar and Kevin Leslie
Affiliation:
Keywords: Interstitial lung disease, mixed connective tissue disease, rheumatic lung disease, rheumatoid lung, scleroderma, Sjogren syndrome, systemic lupus erythematosus.
Abstract: Pulmonary complications associated with autoimmune connective tissue disease (CTD) are common causes of clinical interstitial lung disease (ILD). Pleural manifestations are dominated by inflammation and varying amounts of diffuse fibrosis. In the lung, a wide spectrum of histologic injury patterns are encountered in every anatomic location including small airway disease most commonly in the form of chronic bronchiolitis, vascular changes, and interstitial lung disease ranging from diffuse alveolar damage to advanced pulmonary fibrosis. The most common interstitial pattern, seen in nearly all of the different CTDs, is a cellular and variably fibrotic ILD referred to as nonspecific interstitial pneumonia (NSIP). Each of the major CTDs has particular manifestations more commonly manifested, but the histopathologic changes found in these CTDs are often not specific and a definitive diagnosis usually requires detailed clinical, serologic, and pathologic correlation as well as close patient follow-up.
Export Options
About this article
Cite this article as:
Smith Maxwell, Larsen Brandon, Tazelaar Henry and Leslie Kevin, Histopathology of Connective Tissue Disease-Associated Pleuropulmonary Disease, Current Respiratory Medicine Reviews 2015; 11 (2) . https://dx.doi.org/10.2174/1573398X11666150619175744
DOI https://dx.doi.org/10.2174/1573398X11666150619175744 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
ECMO for Refractory Hypoxia; Current State of the Art and Future Directions
Current Respiratory Medicine Reviews Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes
Current Drug Metabolism Recent Advances in Pulmonary Hypertension Therapy
Recent Patents on Cardiovascular Drug Discovery Transcatheter Embolization Therapy in Liver Cancer
Recent Patents on Medical Imaging Role of Cytokines in the Pathophysiology of Acute Graft-Versus-Host Disease (GVHD)– Are Serum/Plasma Cytokines Potential Biomarkers for Diagnosis of Acute GVHD Following Allogeneic Hematopoietic Cell Transplantation (Allo-HCT)?
Current Stem Cell Research & Therapy Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass — Current and Future Directions
Current Cardiology Reviews Twin-to-Twin Transfusion Syndrome: Diagnosis and Treatment
Current Women`s Health Reviews Treatment and Outcome of Pulmonary Arterial Hypertension in HIVInfected Patients: A Review of the Literature
Current HIV Research Microvascular Diseases: Is A New Era Coming?
Cardiovascular & Hematological Agents in Medicinal Chemistry Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy
Mini-Reviews in Medicinal Chemistry Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Current Pharmaceutical Design Biochemical and Pharmacologic Heterogeneity in Low Molecular Weight Heparins. Impact on the Therapeutic Profile
Current Pharmaceutical Design Emerging Therapy Options in Heparin-Induced Thrombocytopenia
Cardiovascular & Hematological Agents in Medicinal Chemistry Radiological Diagnosis of Renal Thrombosis in Children
Current Pediatric Reviews Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease
Current Topics in Medicinal Chemistry Pulmonary Arterial Hypertension in Connective Tissue Diseases
Current Respiratory Medicine Reviews Potential Role of ADAMTS13 in the Progression of Alcoholic Hepatitis
Current Drug Abuse Reviews Pulmonary Hypertension and Lung Transplantation
Current Hypertension Reviews Genetic Variations of the Hemostatic System as Risk Factors for Venous and Arterial Thrombotic Disease
Current Genomics Radionuclide Liver Cancer Therapies: From Concept to Current Clinical Status
Anti-Cancer Agents in Medicinal Chemistry