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摘要
孕酮受体膜组分1和2,neudesin和neuferricin均属于膜孕激素受体(MAPR)家庭。最近,性类固醇膜受体因为潜在参与了性激素介导的快速非基因组的效应已获得了关注,目前尚不能解释核受体的基因组作用。孕酮可能通过包括丝裂原活化蛋白激酶的活化(MAPK)以及通过MAPRs的磷脂酰肌醇3激酶(PI3K)通路的非基因组效应来增加细胞的增殖和存活。此外,MAPRs独特的表达表明它们可能被用来作为生物标志物以及与性激素有关的癌症和其他疾病的药物靶点。在这篇综述中,我们总结了MAPRs的生理作用,提供一个全面的概述,关于他们的孕激素介导的非基因组作用的新见解,并讨论了其潜在的治疗靶点。
关键词: 孕酮;PGRMC1; PGRMC2;neudesin;neuferricin;癌症。
Current Drug Targets
Title:Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets
Volume: 17 Issue: 10
Author(s): Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa, Ikuo Kimura
Affiliation:
关键词: 孕酮;PGRMC1; PGRMC2;neudesin;neuferricin;癌症。
摘要: Progesterone receptor membrane components 1 and 2, neudesin, and neuferricin belong to the membraneassociated progesterone receptor (MAPR) family. Recently, sex steroid membrane receptors have gained attention because of their potential involvement in sex hormone-mediated rapid non-genomic effects, which cannot currently be explained by the genomic action of nuclear receptors. Progesterone may increase cell proliferation and survival via nongenomic effects including the activation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3- kinase (PI3K) pathways through MAPRs. Moreover, the unique expression of MAPRs suggests that they could be used as biomarkers and drug targets for sex steroid-related cancers and other diseases. In this review, we summarize the physiological roles of the MAPRs, provide a comprehensive overview of their progesterone-mediated non-genomic actions, and discuss new insights into their potential as therapeutic targets.
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Cite this article as:
Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa, Ikuo Kimura , Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets, Current Drug Targets 2016; 17 (10) . https://dx.doi.org/10.2174/1389450116666150518102651
DOI https://dx.doi.org/10.2174/1389450116666150518102651 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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