摘要
肝是控制血糖和脂质代谢的关键。肝脏中脂肪过多的积累使肝功能紊乱,并导致脂肪肝的形成。在没有大量饮酒的患者中,非酒精性脂肪性肝(NAFLD)是脂肪肝的常见类型。多种因素和细胞类型导致了NAFLD的发生和发展。饮食中含有提供能量的营养物质以及具有调节作用的微量元素。作为人体必需微量元素,维生素A(VA)在肝脏葡萄糖和脂质代谢等生理功能中起着关键作用。VA主要储存在静止期肝星状细胞(HSC)中。肝细胞促进VA代谢从而改变代谢葡萄糖和脂质的代谢。有趣的是,激活的造血干细胞中VA含量降低并能导致NAFLD的进展。已经有大量研究VA代谢和脂肪肝发展之间联系的报道。本文对现有文献总结,探讨发生在局部肝细胞和肝星状细胞之间、NAFLD发展过程中肝细胞内的VA代谢变化。研究表明,肝星状细胞和肝细胞的相互影响因素可以导致NAFLD的发展。此外,本文讨论了VA过量代谢增加脂肪合成、促进肝细胞脂肪累积的可能机制。这为研究VA代谢在NAFLD发展中的作用提供了一个参考方向。
关键词: 非酒精性脂肪性肝病,维生素A,维甲类物质,肝星状细胞,肝细胞,胰岛素。
Current Drug Targets
Title:The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease
Volume: 16 Issue: 12
Author(s): Guoxun Chen
Affiliation:
关键词: 非酒精性脂肪性肝病,维生素A,维甲类物质,肝星状细胞,肝细胞,胰岛素。
摘要: The liver is essential for the control of glucose and lipid metabolism. Excessive accumulation of fat in the liver disturbs its function and leads to the development of fatty liver diseases. The nonalcoholic fatty liver disease (NAFLD) is a common type of fatty liver disease found in patients who have not consumed significant amount of alcohol. Multiple factors and cell types contribute to the development and progression of NAFLD. Diets contain macronutrients with energy and micronutrients with regulatory roles. As an essential micronutrient, vitamin A (VA), plays critical roles in various physiological functions including the regulation of glucose and lipid homeostasis in the liver. The body’s VA is mainly stored in quiescent hepatic stellate cells (HSCs) in the liver. Hepatocytes actively metabolize VA, and change glucose and lipid metabolism in response to VA metabolites. Interestingly, the activated HSCs lose their VA content and contribute to the NAFLD progression. Significant number of studies have been conducted to investigate the link between VA metabolism and NAFLD development. This review is to summarize current literatures that discuss the changes of VA metabolism occurring locally between hepatocytes and HSCs, and intracellularly in hepatocytes during the course of NAFLD development. It appears that factors derived from HSCs and hepatocytes mutually affect each other, which contributes to NAFLD development. Additionally, this review discusses the potential mechanism by which excessive VA metabolism increases lipogenesis and contributes to fat accumulation in hepatocytes. It offers potential future directions for the study of the role of VA metabolism in the NAFLD development.
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Cite this article as:
Guoxun Chen , The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease, Current Drug Targets 2015; 16 (12) . https://dx.doi.org/10.2174/1389450116666150325231015
DOI https://dx.doi.org/10.2174/1389450116666150325231015 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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