摘要
CD6,是T细胞中的抗原,它是能与抗原受体复合物结合的一种跨膜糖蛋白。正因为如此,它的主要功能是参与TCR介导的信号转导通路的调制调节。然而,越来越多的证据表明,类似于富含半胱氨酸的清道夫受体超家族(srcr-sf)的其他成员,这一古老而传统的清道夫受体也可以作为模式识别受体(PRR)发挥作用。在这里,我们讨论了CD6和微生物损伤相关信号的功能的相互作用以及可溶性CD6治疗细菌感染性疾病的潜在用途。重要的是, CD6微生物识别也有可能对T细胞的活化和分化功能有所影响,这还有待探索。
关键词: 细菌,CD5,CD6,脂多糖,脂磷壁酸,病原相关分子模式(PAMPs),模式识别受体(PRR),肽聚糖,富含半胱氨酸清道夫受体(SRCR)
Current Drug Targets
Title:Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor
Volume: 17 Issue: 6
Author(s): Adelaida Sarukhan, Mario Martinez-Florensa, Cristina Escoda-Ferran, Esther Carrasco, Esther Carreras and Francisco Lozano
Affiliation:
关键词: 细菌,CD5,CD6,脂多糖,脂磷壁酸,病原相关分子模式(PAMPs),模式识别受体(PRR),肽聚糖,富含半胱氨酸清道夫受体(SRCR)
摘要: CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here, we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.
Export Options
About this article
Cite this article as:
Adelaida Sarukhan, Mario Martinez-Florensa, Cristina Escoda-Ferran, Esther Carrasco, Esther Carreras and Francisco Lozano , Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor, Current Drug Targets 2016; 17 (6) . https://dx.doi.org/10.2174/1389450116666150316224308
DOI https://dx.doi.org/10.2174/1389450116666150316224308 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response and/or therapy ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Significance of P2X7 Receptor Variants to Human Health and Disease
Recent Patents on DNA & Gene Sequences Reciprocity in Microbiome and Immune System Interactions and its Implications in Disease and Health
Inflammation & Allergy - Drug Targets (Discontinued) Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Immunopathological Aspects of Mycoplasma pneumoniae Infection
Current Pediatric Reviews Use of Genetically Modified Bacteria to Modulate Adaptive Immunity
Current Gene Therapy Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential
Current Medicinal Chemistry Allergen-Induced Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry T Cell Replicative Senescence in Human Aging
Current Pharmaceutical Design Potential Crossreactivity of Human Immune Responses Against HCMV Glycoprotein B
Current Drug Discovery Technologies Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells
Current Immunology Reviews (Discontinued) Peptides as Therapeutic Agents or Drug Leads for Autoimmune, Hormone Dependent and Cardiovascular Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Palmitoylethanolamide is a New Possible Pharmacological Treatment for the Inflammation Associated with Trauma
Mini-Reviews in Medicinal Chemistry The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders
Current Topics in Medicinal Chemistry Dichotomous Life of DNA Binding High Mobility Group Box1 Protein in Human Health and Disease
Current Protein & Peptide Science Glycolipid Stimulators for NKT Cells Bearing Invariant Vα19-Jα33 TCR α Chains
Mini-Reviews in Medicinal Chemistry Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets CD24 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: Targeting Redundancy for Immunotherapy?
Current Immunology Reviews (Discontinued) The Role of α7 Nicotinic Acetylcholine Receptors and α7-Specific Antibodies in Neuroinflammation Related to Alzheimer Disease
Current Pharmaceutical Design The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
Current Neuropharmacology An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?
Current Pharmaceutical Design