杂环支架：抗癌药发展的中心

Title:Heterocyclic Scaffolds: Centrality in Anticancer Drug Development

Volume: 16 Issue: 7

Author(s): Imran Ali, Mohammad Nadeem Lone, Zeid A. Al-Othman, Abdulrahman Al-Warthan and Mohd. Marsin Sanagi

Affiliation:

关键词: 目前的挑战，未来的展望，杂环化合物，市售抗癌药，作用机理，最新进展，合成的和天然的杂环化合物。

摘要: Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer agents are discussed into the different sections.

Cite this article as:

Imran Ali, Mohammad Nadeem Lone, Zeid A. Al-Othman, Abdulrahman Al-Warthan and Mohd. Marsin Sanagi , Heterocyclic Scaffolds: Centrality in Anticancer Drug Development, Current Drug Targets 2015; 16 (7) . https://dx.doi.org/10.2174/1389450116666150309115922