Abstract
MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding the role of miRNAs in the intracellular space may be vital in understanding the mechanism of certain diseases.
Keywords: Cancer, endoplasmic reticulum, miRNA, mitochondria, organelles, P-bodies.
MicroRNA
Title:MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease
Volume: 3 Issue: 2
Author(s): Thao T. Nguyen, Ekua W. Brenu, Don R. Staines and Sonya M. Marshall-Gradisnik
Affiliation:
Keywords: Cancer, endoplasmic reticulum, miRNA, mitochondria, organelles, P-bodies.
Abstract: MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding the role of miRNAs in the intracellular space may be vital in understanding the mechanism of certain diseases.
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Cite this article as:
Nguyen T. Thao, Brenu W. Ekua, Staines R. Don and Marshall-Gradisnik M. Sonya, MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease, MicroRNA 2014; 3 (2) . https://dx.doi.org/10.2174/2211536604666141218154252
DOI https://dx.doi.org/10.2174/2211536604666141218154252 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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