Abstract
During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively wellcharacterized toxicity profiles due to several decades of use for treatment of malaria. Previously published review articles provide an excellent overview of the diversity of chloroquine effects on cancer cells, both in the cell culture as well as on human tumors grafted into mice; and an account of the increasing pace of incorporation of hydroxychloroquine in combination treatment schemes for clinical studies. In this review we present some features that are common between cancers that are sensitive to quinoline derivatives, in particular features that are amenable to pharmaceutical intervention.
Keywords: Chloroquine, cancer, autophagy, lysosome, immunity.
Current Drug Targets
Title:New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy
Volume: 15 Issue: 9
Author(s): Spiros Vlahopoulos, Elena Critselis, Ioannis F. Voutsas, Sonia A. Perez, Maria Moschovi, Constantin N. Baxevanis and George P. Chrousos
Affiliation:
Keywords: Chloroquine, cancer, autophagy, lysosome, immunity.
Abstract: During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively wellcharacterized toxicity profiles due to several decades of use for treatment of malaria. Previously published review articles provide an excellent overview of the diversity of chloroquine effects on cancer cells, both in the cell culture as well as on human tumors grafted into mice; and an account of the increasing pace of incorporation of hydroxychloroquine in combination treatment schemes for clinical studies. In this review we present some features that are common between cancers that are sensitive to quinoline derivatives, in particular features that are amenable to pharmaceutical intervention.
Export Options
About this article
Cite this article as:
Vlahopoulos Spiros, Critselis Elena, Voutsas F. Ioannis, Perez A. Sonia, Moschovi Maria, Baxevanis N. Constantin and Chrousos P. George, New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy, Current Drug Targets 2014; 15 (9) . https://dx.doi.org/10.2174/1389450115666140714121514
DOI https://dx.doi.org/10.2174/1389450115666140714121514 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response and/or therapy ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Abscopal Effect of Radiation Therapy and Signal Transduction
Current Signal Transduction Therapy Pleiotropic Role of HSF1 in Neoplastic Transformation
Current Cancer Drug Targets Reversing Aberrant Methylation Patterns in Cancer
Current Medicinal Chemistry Is Type D Personality Here to Stay? Emerging Evidence Across Cardiovascular Disease Patient Groups
Current Cardiology Reviews Functional Food with Some Health Benefits, So Called Superfood: A Review
Current Nutrition & Food Science Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy
Current Molecular Pharmacology Disorders of Protein Biogenesis and Stability
Protein & Peptide Letters Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
Current Molecular Pharmacology New Prospects for Nelfinavir in Non-HIV-Related Diseases
Current Molecular Pharmacology Antiviral Compounds Derived from Naturally Occurring Proteins
Current Medicinal Chemistry - Anti-Infective Agents Obesity Modulation - The Role in Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Preclinical Evaluation of New Taxoids
Current Pharmaceutical Design From TGF-β to Cancer Therapy
Current Drug Targets Molecular Processes Exploited as Drug Targets for Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Advances in Nano Drugs for Cancer Chemotherapy
Current Cancer Drug Targets Editorial (Hot Topic: Cancer Imaging: Progress and Prospect)
Current Molecular Imaging (Discontinued) Inflammation and Antiangiogenesis in Cancer
Current Medicinal Chemistry Connexins as Precocious Markers and Molecular Targets for Chemical and Pharmacological Agents in Carcinogenesis
Current Medicinal Chemistry Lipid Nanoparticles to Deliver miRNA in Cancer
Current Pharmaceutical Biotechnology Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery