Abstract
Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.
Keywords: Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.
Current Drug Delivery
Title:Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis
Volume: 11 Issue: 6
Author(s): Manitha Nair and Amit Krishnan
Affiliation:
Keywords: Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.
Abstract: Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.
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Cite this article as:
Nair Manitha and Krishnan Amit, Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis, Current Drug Delivery 2014; 11 (6) . https://dx.doi.org/10.2174/1567201811666140414120002
DOI https://dx.doi.org/10.2174/1567201811666140414120002 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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