Abstract
“The incidence of thyroid cancer, the most common endocrine malignancy, is rising. The two most common types of thyroid cancer are papillary and follicular” thyroid carcinomas. “Fine-needle aspiration (FNA) of thyroid nodules” can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)γ and “RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas” (more than 70% of cases), which can be used successfully to improve the diagnosis “and the management of patients with thyroid nodules”. The most extensive experience has been accumulated with “the diagnostic use of BRAF mutation”, which is highly specific for malignancy. “Testing FNA samples for a panel of mutations” that typically includes RAS, BRAF, PAX8/PPAR and RET/PTC could permit to achieve the biggest diagnostic impact. “The accuracy of cancer diagnosis in thyroid nodules could be improved significantly using these and other emerging molecular markers”.
Keywords: Thyroid nodules, Thyroid cancer, Cytology, RET, BRAF, RAS, PAX8/PPARγ.
Current Genomics
Title:Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
Volume: 15 Issue: 3
Author(s): Poupak Fallahi, Riccardo Giannini, Paolo Miccoli, Alessandro Antonelli and Fulvio Basolo
Affiliation:
Keywords: Thyroid nodules, Thyroid cancer, Cytology, RET, BRAF, RAS, PAX8/PPARγ.
Abstract: “The incidence of thyroid cancer, the most common endocrine malignancy, is rising. The two most common types of thyroid cancer are papillary and follicular” thyroid carcinomas. “Fine-needle aspiration (FNA) of thyroid nodules” can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)γ and “RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas” (more than 70% of cases), which can be used successfully to improve the diagnosis “and the management of patients with thyroid nodules”. The most extensive experience has been accumulated with “the diagnostic use of BRAF mutation”, which is highly specific for malignancy. “Testing FNA samples for a panel of mutations” that typically includes RAS, BRAF, PAX8/PPAR and RET/PTC could permit to achieve the biggest diagnostic impact. “The accuracy of cancer diagnosis in thyroid nodules could be improved significantly using these and other emerging molecular markers”.
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Cite this article as:
Fallahi Poupak, Giannini Riccardo, Miccoli Paolo, Antonelli Alessandro and Basolo Fulvio, Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules, Current Genomics 2014; 15 (3) . https://dx.doi.org/10.2174/1389202915999140404100347
DOI https://dx.doi.org/10.2174/1389202915999140404100347 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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