Abstract
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The accumulation of mature CD5(+) B-lymphocytes in bone marrow, peripheral blood, and lymphoid organs due to decreased apoptosis is a characteristic of this malignancy. MicroRNAs (miRNAs) are small noncoding RNAs able to regulate the expression of many target genes, including the main apoptosis regulators BCL2 and MCL1. miRNAs play key roles in the pathogenesis of CLL, including specific miRNAs located at the 13q14 chromosomal region that is often deleted or mutated in patients with CLL. In this paper, we review new investigations that underscore the significance of miRNAs for CLL pathogenesis.
Keywords: Apoptosis, leukemia, long non-codingRNAs, microRNAs, prognostic, treatment.
MicroRNA
Title:MicroRNAs as Main Players in the Pathogenesis of Chronic Lymphocytic Leukemia
Volume: 2 Issue: 3
Author(s): Arianna Bottoni and George A. Calin
Affiliation:
Keywords: Apoptosis, leukemia, long non-codingRNAs, microRNAs, prognostic, treatment.
Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The accumulation of mature CD5(+) B-lymphocytes in bone marrow, peripheral blood, and lymphoid organs due to decreased apoptosis is a characteristic of this malignancy. MicroRNAs (miRNAs) are small noncoding RNAs able to regulate the expression of many target genes, including the main apoptosis regulators BCL2 and MCL1. miRNAs play key roles in the pathogenesis of CLL, including specific miRNAs located at the 13q14 chromosomal region that is often deleted or mutated in patients with CLL. In this paper, we review new investigations that underscore the significance of miRNAs for CLL pathogenesis.
Export Options
About this article
Cite this article as:
Bottoni Arianna and Calin A. George, MicroRNAs as Main Players in the Pathogenesis of Chronic Lymphocytic Leukemia, MicroRNA 2013; 2 (3) . https://dx.doi.org/10.2174/2211536602666131126002337
DOI https://dx.doi.org/10.2174/2211536602666131126002337 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Revolutionizing Animal Farming: The Impact of miRNAs on Health and Productivity
The utilization of microRNAs (miRNAs) in animal production represents an emerging frontier in agricultural biotechnology, with the potential to revolutionize the sector. MiRNAs, small non-coding RNA molecules, play a crucial role in regulating gene expression, influencing vital processes such as growth, muscle development, disease resistance, and feed efficiency. Their application ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Tumor Necrosis Factor-α-Mediated Pulmonary Endothelial Barrier Dysfunction
Current Respiratory Medicine Reviews Microfilament Actin Remodeling as a Potential Target for Cancer Drug Development
Current Cancer Drug Targets New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia
Current Cancer Drug Targets Regulatory Mechanisms of Calcineurin Phosphatase Activity
Current Medicinal Chemistry A Novel Gene Selection Algorithm based on Sparse Representation and Minimum-redundancy Maximum-relevancy of Maximum Compatibility Center
Current Proteomics Radiation Dosimetry Aspects of <sup>177</sup>Lu
Current Radiopharmaceuticals Oxidative Stress and its Clinical Consequences: Relationship between Diabetes and Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Recent Development in the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors for Non-small Cell Lung Cancer
Current Medicinal Chemistry Recent Approaches on Novel Topical Delivery Systems for Atopic Dermatitis Treatment
Recent Patents on Drug Delivery & Formulation Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery
Mini-Reviews in Medicinal Chemistry Atypical GTPases as Drug Targets
Anti-Cancer Agents in Medicinal Chemistry Medicinal Plant-derived Phytochemicals in Detoxification
Current Pharmaceutical Design Tocotrienols and Cancer: From the State of the Art to Promising Novel Patents
Recent Patents on Anti-Cancer Drug Discovery Alterations within the Osteo-Hematopoietic Niche in MDS and their Therapeutic Implications
Current Pharmaceutical Design Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist
Current Topics in Medicinal Chemistry FLT3 as a Therapeutic Target in Childhood Acute Leukemia
Current Drug Targets Experimental and Computational Approaches to Improve Binding Affinity in Chemical Biology and Drug Discovery
Current Topics in Medicinal Chemistry Oncogenic Fusion Tyrosine Kinases as Molecular Targets for Anti-Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review
Current Molecular Medicine microRNAs in Cancer: Lessons from Melanoma
Current Pharmaceutical Design