Abstract
Platinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and oxaliplatin are neutral platinum (II) complexes with two amine ligands and two additional ligands that can be aquated for further binding with DNA. The platinum-DNA adducts can impede cellular process and lead to cellular apoptosis. Tumor resistance to platinum drugs has become a very challenging problem to overcome. Individualized cancer treatment using different strategies to circumvent the platinum-drug resistance in cancer patients is of great importance. Structural modification of traditional platinum drugs, combination therapy using platinum drugs with other agents and improved delivery of platinum drug to tumor sites are major strategies developed to overcome existed problems in chemotherapy using traditional platinum drugs. Platinum-based agents with respect to their structure, mechanism of action and strategies developed for improved efficacy in cancer treatment have been summarized in this paper with the perspective of developing new platinum drugs or platinum-based therapy for individualized cancer treatment.
Keywords: Cancer chemotherapy, personalized medicine, platinum-based agents, platinum drug delivery, platinum drug resistance.
Current Molecular Medicine
Title:Platinum-Based Agents for Individualized Cancer Treatment
Volume: 13 Issue: 10
Author(s): X. Chen, Y. Wu, H. Dong, C. Y. Zhang and Y. Zhang
Affiliation:
Keywords: Cancer chemotherapy, personalized medicine, platinum-based agents, platinum drug delivery, platinum drug resistance.
Abstract: Platinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and oxaliplatin are neutral platinum (II) complexes with two amine ligands and two additional ligands that can be aquated for further binding with DNA. The platinum-DNA adducts can impede cellular process and lead to cellular apoptosis. Tumor resistance to platinum drugs has become a very challenging problem to overcome. Individualized cancer treatment using different strategies to circumvent the platinum-drug resistance in cancer patients is of great importance. Structural modification of traditional platinum drugs, combination therapy using platinum drugs with other agents and improved delivery of platinum drug to tumor sites are major strategies developed to overcome existed problems in chemotherapy using traditional platinum drugs. Platinum-based agents with respect to their structure, mechanism of action and strategies developed for improved efficacy in cancer treatment have been summarized in this paper with the perspective of developing new platinum drugs or platinum-based therapy for individualized cancer treatment.
Export Options
About this article
Cite this article as:
Chen X., Wu Y., Dong H., Zhang Y. C. and Zhang Y., Platinum-Based Agents for Individualized Cancer Treatment, Current Molecular Medicine 2013; 13 (10) . https://dx.doi.org/10.2174/1566524013666131111125515
DOI https://dx.doi.org/10.2174/1566524013666131111125515 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Nimesulide and Its Analogues in Cancer Chemoprevention
Anti-Cancer Agents in Medicinal Chemistry Quantitative Analysis of UGT2B28 mRNA Expression by Real-Time RT-PCR and Application to Human Tissue Distribution Study
Drug Metabolism Letters ROS Modulate Cell Death Mechanism in Cervical Cancer Cells Treated with the Combination of Polyphenolic Compounds and Anticancer Drug Cisplatin: A Review
Current Cancer Therapy Reviews Diabetes-induced Epigenetic Signature in Vascular Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets MRI Plain Scan: A Tool in the Management of Cervical Cancer during Pregnancy
Current Medical Imaging MR Imaging Findings of Uterine Cervical Carcinoma
Current Medical Imaging Beetroot Bioactive and its Associated Health Benefits: Considerations for Utilization of Beetroot in Value-added Products
Recent Advances in Food, Nutrition & Agriculture Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells
Current Pharmaceutical Design Targeting the Multifaceted HuR Protein, Benefits and Caveats
Current Drug Targets Protein Kinases as Drug Targets in Human and Animal Diseases
Current Enzyme Inhibition Radiolabelled Quinoline Derivaties for the PET Imaging of Peripheral Benzodiazepine Receptor
Current Medical Imaging Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies
Current Molecular Medicine Targeting Molecular Imaging of Breast Cancer by Radioimmunodetection Method in Nuclear Medicine
Current Molecular Imaging (Discontinued) Strategies for In Vivo siRNA Delivery in Cancer
Mini-Reviews in Medicinal Chemistry Evolution of Ipsilateral Head and Neck Radiotherapy
Current Cancer Therapy Reviews Understanding Epithelial-Mesenchymal Transition may Reveal Novel Therapeutic Targets for Oral Squamous Cell Carcinoma
Current Cancer Therapy Reviews Computational Methods and Algorithms for Mass Spectrometry Based Differential Proteomics: Recent Advances, Perspectives and Open Problems
Current Proteomics Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation
Current Cancer Drug Targets Molecular Mechanisms Underlying St. Johns Wort Drug Interactions
Current Drug Metabolism Synthesis of Drugs and Biorelevant N-heterocycles Employing Recent Advances in C-N Bond Formation
Current Organic Chemistry