Abstract
A series of new N-pyrazolylbenzamides (5a–x) were synthesized by aroylation of 5-amino-1-phenyl-3-tbutylpyrazole. The structures of synthesized compounds were established based on spectral (FTIR, 1H NMR, ESI Mass) analysis and purity was ascertained by HPLC. The antibacterial screening revealed that seven molecules exhibited an excellent antibacterial activity and eight compounds demonstrated considerable antifungal activity. Three molecules of the series 5e, 5s and 5w were found to be highly effective against Klebsilla pneumoneia with MIC of 3.12 µg/ml. Compounds 5b, 5f, 5g and 5o exhibited significant antitubercular activity with MIC of 12.5 µg/ml.
Keywords: Benzamides, antibacterial, antifungal, antitubercular.
Medicinal Chemistry
Title:Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide Derivatives
Volume: 10 Issue: 2
Author(s): Ravindra Kulkarni, Vijaykumar, Harish Babu, Krishna Kumar, Naveen Gaddam, Aneesa Fatima, Sudhakar Muvvala, Bhikshapathi D V R N, Sriram D, Achaiah Garlapati, Jagrut Vishnav and Prashant Gurav
Affiliation:
Keywords: Benzamides, antibacterial, antifungal, antitubercular.
Abstract: A series of new N-pyrazolylbenzamides (5a–x) were synthesized by aroylation of 5-amino-1-phenyl-3-tbutylpyrazole. The structures of synthesized compounds were established based on spectral (FTIR, 1H NMR, ESI Mass) analysis and purity was ascertained by HPLC. The antibacterial screening revealed that seven molecules exhibited an excellent antibacterial activity and eight compounds demonstrated considerable antifungal activity. Three molecules of the series 5e, 5s and 5w were found to be highly effective against Klebsilla pneumoneia with MIC of 3.12 µg/ml. Compounds 5b, 5f, 5g and 5o exhibited significant antitubercular activity with MIC of 12.5 µg/ml.
Export Options
About this article
Cite this article as:
Kulkarni Ravindra, Vijaykumar , Babu Harish, Kumar Krishna, Gaddam Naveen, Fatima Aneesa, Muvvala Sudhakar, N D V R Bhikshapathi, D Sriram, Garlapati Achaiah, Vishnav Jagrut and Gurav Prashant, Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide Derivatives, Medicinal Chemistry 2014; 10 (2) . https://dx.doi.org/10.2174/15734064113099990039
DOI https://dx.doi.org/10.2174/15734064113099990039 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
State of the Art Review and Report of New Tool for Drug Discovery
Current Topics in Medicinal Chemistry Computer-aided Structural and Molecular Insights into the Mechanisms by which Pseudouridimycin (PUM) Disrupts Cleft Extension in Bacterial RNA Polymerase to Block DNA Entry and Exit
Letters in Drug Design & Discovery Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Reviews on Recent Clinical Trials Antibiotics in the Treatment of Reactive Arthritis
Current Rheumatology Reviews An Optimal Model Combining SqueezeNet and Machine Learning Methods for Lung Disease Diagnosis
Current Medical Imaging Recent Progress in the Synthesis of Isoxazoles
Current Organic Chemistry Control Policies and Interventions Focusing on Malaria in Pregnancy
Current Women`s Health Reviews Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity
Letters in Drug Design & Discovery Toward Integrase Defective Lentiviral Vectors for Genetic Immunization
Current HIV Research Eradicating Bacterial Biofilms with Natural Products and their Inspired Analogues that Operate Through Unique Mechanisms
Current Topics in Medicinal Chemistry The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review
Current Neuropharmacology Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application
Current Drug Research Reviews Development of a Multi-Compartmental Oral Vaccine Delivery System
Drug Delivery Letters Antimicrobial Compounds from Marine Invertebrates-Derived Microorganisms
Current Medicinal Chemistry Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials
Current Pharmaceutical Biotechnology Cofactor Biosynthetic Pathways in Mycobacterium tuberculosis as Potential Drug Targets
Current Respiratory Medicine Reviews Bacterial Infection in Head and Neck Space Regions: A Narrative Review
New Emirates Medical Journal Molecular Approach to Targeted Therapy for Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Preface:
Anti-Infective Agents Nanochemistry-Based Immunotherapy for HIV-1
Current Medicinal Chemistry