Abstract
This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
Keywords: Nanotechnologies, nanoparticles, gene therapy, anticancer drugs, drug carriers, cancer, cytostatic, targeted therapy.
Current Drug Metabolism
Title:Nanocarriers for Anticancer Drugs - New Trends in Nanomedicine
Volume: 14 Issue: 5
Author(s): Jana Drbohlavova, Jana Chomoucka, Vojtech Adam, Marketa Ryvolova, Tomas Eckschlager, Jaromir Hubalek and Rene Kizek
Affiliation:
Keywords: Nanotechnologies, nanoparticles, gene therapy, anticancer drugs, drug carriers, cancer, cytostatic, targeted therapy.
Abstract: This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
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Drbohlavova Jana, Chomoucka Jana, Adam Vojtech, Ryvolova Marketa, Eckschlager Tomas, Hubalek Jaromir and Kizek Rene, Nanocarriers for Anticancer Drugs - New Trends in Nanomedicine, Current Drug Metabolism 2013; 14 (5) . https://dx.doi.org/10.2174/1389200211314050005
DOI https://dx.doi.org/10.2174/1389200211314050005 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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