Abstract
The role of various structural features, namely basic scaffolds and substituents of small molecule inhibitors of the self-assembly of amyloid-beta (Aβ) peptide, a key process in Alzheimer’s disease, is described. The literature analysis in this update extends to the past 5 years, thus the past 15 year period is covered. In addition, while our previous review was limited to anti-fibril agents the current update includes compounds with a major profile in oligomer inhibition as well, and covers inhibitors of the broadly defined Aβ self-assembly. Basis sets of 507 fibrillogenesis inhibitors and 154 oligomer formation inhibitors were surveyed and a chemical map of the inhibitors is provided highlighting the most common substituents that appear in these compounds.
Keywords: Alzheimer’s disease, amyloid, amyloid-beta peptide, self-assembly, fibrils, oligomers, small molecule inhibitors, structure-activity relationship
Current Bioactive Compounds
Title:Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors
Volume: 9 Issue: 1
Author(s): Bela Torok, Seema Bag, Madhura Sarkar, Sujaya Dasgupta and Marianna Torok
Affiliation:
Keywords: Alzheimer’s disease, amyloid, amyloid-beta peptide, self-assembly, fibrils, oligomers, small molecule inhibitors, structure-activity relationship
Abstract: The role of various structural features, namely basic scaffolds and substituents of small molecule inhibitors of the self-assembly of amyloid-beta (Aβ) peptide, a key process in Alzheimer’s disease, is described. The literature analysis in this update extends to the past 5 years, thus the past 15 year period is covered. In addition, while our previous review was limited to anti-fibril agents the current update includes compounds with a major profile in oligomer inhibition as well, and covers inhibitors of the broadly defined Aβ self-assembly. Basis sets of 507 fibrillogenesis inhibitors and 154 oligomer formation inhibitors were surveyed and a chemical map of the inhibitors is provided highlighting the most common substituents that appear in these compounds.
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Cite this article as:
Torok Bela, Bag Seema, Sarkar Madhura, Dasgupta Sujaya and Torok Marianna, Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors, Current Bioactive Compounds 2013; 9 (1) . https://dx.doi.org/10.2174/1573407211309010006
DOI https://dx.doi.org/10.2174/1573407211309010006 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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