Abstract
Nestin is an intermediate filament protein expressed in neuroepithelial stem cells during development and it is later replaced by cell specific neuronal or glial filaments. Nevertheless, nestin+ cells remain within adult tissues and they can be regarded as potential neural stem cell (NSC). Nestin+ cells have been detected in Schwann cells related with sensory corpuscles of rodent and they have been demonstrated to be NSC. We have investigated the existence of nestin+ in human cutaneous cells Meissner and Pacinian corpuscles through the use of immunohistochemistry techniques and in situ hybridization. S100 protein (also regarded as a marker for NSC) and vimentin (the intermediate filament of mature Schwann cells in sensory corpuscles) were also investigated. The results show that the adult human cutaneous sensory Meissner and Pacinian corpuscles contains a small population of Schwann-related cells (vimentin+) which on the basis of their basic immunohistochemical characteristics (S100 protein+, nestin+) can be potential NSCs. Cells sharing identical immunohistochemical profile were also found in the close vicinity of Meissner corpuscles. Because their localization they are easily accessible and may represent a peripheral niche of NSC to be used for therapeutic goals.
Keywords: Nestin, Meissner corpuscles, Pacianian corpuscles, immunohistochemistry, human skin, neural stem cell, neuroepithelial, potential neural stem cell, Schwann cells, therapeutic goals
CNS & Neurological Disorders - Drug Targets
Title:Evidence of Nestin-Positive Cells in the Human Cutaneus Meissner and Pacinian Corpuscles
Volume: 11 Issue: 7
Author(s): Marta Calavia, Eliso Vina, Manuel Menendez-Gonzalez, Alfonso Lopez-Muniz, Marta Alonso-Guervos, Juan Cobo, Jesus Otero, Oscar Arias-Carrion, Jose Antonio Vega and Olivia Garcia-Suarez
Affiliation:
Keywords: Nestin, Meissner corpuscles, Pacianian corpuscles, immunohistochemistry, human skin, neural stem cell, neuroepithelial, potential neural stem cell, Schwann cells, therapeutic goals
Abstract: Nestin is an intermediate filament protein expressed in neuroepithelial stem cells during development and it is later replaced by cell specific neuronal or glial filaments. Nevertheless, nestin+ cells remain within adult tissues and they can be regarded as potential neural stem cell (NSC). Nestin+ cells have been detected in Schwann cells related with sensory corpuscles of rodent and they have been demonstrated to be NSC. We have investigated the existence of nestin+ in human cutaneous cells Meissner and Pacinian corpuscles through the use of immunohistochemistry techniques and in situ hybridization. S100 protein (also regarded as a marker for NSC) and vimentin (the intermediate filament of mature Schwann cells in sensory corpuscles) were also investigated. The results show that the adult human cutaneous sensory Meissner and Pacinian corpuscles contains a small population of Schwann-related cells (vimentin+) which on the basis of their basic immunohistochemical characteristics (S100 protein+, nestin+) can be potential NSCs. Cells sharing identical immunohistochemical profile were also found in the close vicinity of Meissner corpuscles. Because their localization they are easily accessible and may represent a peripheral niche of NSC to be used for therapeutic goals.
Export Options
About this article
Cite this article as:
Calavia Marta, Vina Eliso, Menendez-Gonzalez Manuel, Lopez-Muniz Alfonso, Alonso-Guervos Marta, Cobo Juan, Otero Jesus, Arias-Carrion Oscar, Antonio Vega Jose and Garcia-Suarez Olivia, Evidence of Nestin-Positive Cells in the Human Cutaneus Meissner and Pacinian Corpuscles, CNS & Neurological Disorders - Drug Targets 2012; 11 (7) . https://dx.doi.org/10.2174/1871527311201070869
DOI https://dx.doi.org/10.2174/1871527311201070869 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Heart and Brain Axis Targets in CNS Neurological Disorders
Recently there has been a surge of interest in delving deeper into the complex interplay between the heart and brain. This fascination stems from a growing recognition of the profound influence each organ holds over the other, particularly in the realm of central nervous system (CNS) neurological disorders. The purpose ...read more
Lifestyle Interventions to Prevent and Treat Cognitive Impairment and Dementia
More than 55 million people live with dementia worldwide. By 2050, the population affected by dementia will exceed 139 million individuals. Mild cognitive impairment (MCI) is a pre-dementia stage, also known as prodromal dementia, affecting older adults. MCI emerges years before the manifestation of dementia but can be avoidable and ...read more
Novel Treatments in Subarachnoid Hemorrhage
The current landscape of therapeutic strategies for subarachnoid hemorrhage (SAH), a significant adverse neurological event commonly resulting from the rupture of intracranial aneurysms, is rapidly evolving. Through an in-depth exploration of the natural history of SAH, historical treatment approaches, and emerging management modalities, the present work aims to provide a ...read more
Pathogenic Proteins in Neurodegenerative Diseases: From Mechanisms to Treatment Modalities
The primary objective of this thematic issue is to elucidate the molecular mechanisms by which pathogenic proteins contribute to neurodegenerative diseases and to highlight current and emerging therapeutic strategies aimed at mitigating their effects. By bringing together cutting-edge research and reviews, this issue aims to: 1.Enhance Understanding: Provide a comprehensive ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Patents in Cardiac Resynchronization Therapy
Recent Patents on Biomedical Engineering (Discontinued) NAD<sup>+</sup>/NADH Metabolism and NAD<sup>+</sup>-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications
Current Medicinal Chemistry Patents and the Development on Polymer based Nanomaterial (PAMAM Dendrimer) for Biomedical Applications
Recent Patents on Biomedical Engineering (Discontinued) Blockade of Apoptosis by ACE Inhibitors and Angiotensin Receptor Antagonists
Current Pharmaceutical Design LHON: Mitochondrial Mutations and More
Current Genomics Long-term Effects of Early Exposure to Stress, Pain, Opioids and Anaesthetics on Pain Sensitivity and Neurocognition
Current Pharmaceutical Design Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers
Current Drug Metabolism Pharmacogenetics of Selective Serotonin Reuptake Inhibitor Response in Major Depression
Current Pharmacogenomics Endothelial Dysfunction in Cardiac Allograft Vasculopathy: Potential Pharmacological Interventions
Current Vascular Pharmacology Chloride Channels − New Targets for the Prevention of Stroke
Current Vascular Pharmacology Applications of Nanomaterials for Cancer Treatment: Recent Patents Review
Recent Patents on Nanomedicine Targeting Kinin Receptors for the Treatment of Neurological Diseases
Current Pharmaceutical Design Prominent Perspective on Existing Biological Hallmarks of Alzheimer’s Disease
Current Topics in Medicinal Chemistry Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?
CNS & Neurological Disorders - Drug Targets Treatment of Chronic Peripheral Arterial Disease
Current Vascular Pharmacology Multifunctional Tacrine Derivatives in Alzheimer’s Disease
Current Topics in Medicinal Chemistry Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
Current Pharmaceutical Design Blood Stem Cells and non-Hematological Clinical Practice: Pragmatics Before Therapeutics
Current Pharmaceutical Biotechnology Novel Insights into the Molecular Mechanisms Involved in the Neuroprotective Effects of C-Phycocyanin against Brain Ischemia in Rats
Current Pharmaceutical Design miRNAs in Alzheimer Disease – A Therapeutic Perspective
Current Alzheimer Research