Abstract
Up to date, it has been reported that several bioactive natural compounds can modulate bone metabolism. It has been also disclosed that some of them simultaneously modulate the immune response. Thus, understanding the molecular mechanisms surrounding bone metabolism has moved bone research into a new era and recently the term “osteoimmunology” is coined to describe new interdisciplinary field of bone and immunology. Now, therefore bone research is one of the hot spots designing novel drugs. Notably, the role of phytoestrogens represented by isoflavones in the bone health was frequently reviewed; however only a few reviews thoroughly cover the field of bioactive natural compounds in bone metabolism. In this review, we summarize current status of representative bioactive natural compounds that modulate bone metabolism and present new therapeutic approaches in the near future by focusing on three classes of compounds phytoestrogens, polyunsaturated fatty acids and lactoferrin.
Keywords: Osteoporosis, bone, natural compounds, phytoestrogens, isoflavones, polyunsaturated fatty acids, omega-3, lactoferrin
Current Bioactive Compounds
Title: Bone Modulating Bioactive Natural Compounds: Review
Volume: 3 Issue: 3
Author(s): Kanji Mori, Dominique Heymann and Ronan Le Bot
Affiliation:
Keywords: Osteoporosis, bone, natural compounds, phytoestrogens, isoflavones, polyunsaturated fatty acids, omega-3, lactoferrin
Abstract: Up to date, it has been reported that several bioactive natural compounds can modulate bone metabolism. It has been also disclosed that some of them simultaneously modulate the immune response. Thus, understanding the molecular mechanisms surrounding bone metabolism has moved bone research into a new era and recently the term “osteoimmunology” is coined to describe new interdisciplinary field of bone and immunology. Now, therefore bone research is one of the hot spots designing novel drugs. Notably, the role of phytoestrogens represented by isoflavones in the bone health was frequently reviewed; however only a few reviews thoroughly cover the field of bioactive natural compounds in bone metabolism. In this review, we summarize current status of representative bioactive natural compounds that modulate bone metabolism and present new therapeutic approaches in the near future by focusing on three classes of compounds phytoestrogens, polyunsaturated fatty acids and lactoferrin.
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Cite this article as:
Mori Kanji, Heymann Dominique and Bot Le Ronan, Bone Modulating Bioactive Natural Compounds: Review, Current Bioactive Compounds 2007; 3 (3) . https://dx.doi.org/10.2174/157340707781695613
DOI https://dx.doi.org/10.2174/157340707781695613 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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