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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances in Medicinal Chemistry of Sulfonamides. Rational Design as Anti-Tumoral, Anti-Bacterial and Anti-Inflammatory Agents

Author(s): Syed Shoaib Ahmad Shah, Gildardo Rivera and Muhammad Ashfaq

Volume 13, Issue 1, 2013

Page: [70 - 86] Pages: 17

DOI: 10.2174/1389557511307010070

Price: $65

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Abstract

Now-a-days, cancer is becoming one of the major problems of public health in the world. Pharmacology treatment is a way to increase quality and long life. Predominantly, in last decade sulfonamide derivatives have been described as potential carbonic anhydrase inhibitors. In the present work, we describe recent advances during the last decade in medicinal chemistry of sulfonamides derivatives with some examples of rational design as anti-tumoral, antibacterial and anti-inflammatory agents. We show strategy design, structure-activity relationship, biological activity and advances of new sulfonamide compounds that have more health significance than some clinically used sulfonamides.

Keywords: Anti-bacterial, Anti-inflammatory, Anti-tumoral, Biological activity, Sulfonamide, Structure-activity relationship, Clinical use


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