Abstract
Patent ductus arteriosus is a common problem in very low birth weight infants. Prostaglandin synthesis inhibitors such as indomethacin and ibuprofen are widely used preferred medications for ductal closure but the question of which one should be preferred is controversial. There are some studies in the literature comparing their pharmacokinetics, efficacy, side effects and long-term outcomes. In this review we aimed to focus on prostaglandin synthesis inhibitors with their pharmacodynamic and pharmacokinetic in relation to oral and intravenous forms. Oral ibuprofen seems to be an effective and cheap alternative to the intravenous forms. Studies in extremely low birth weight infants that also evaluate the neurodevelopment will clarify its use.
Keywords: Ibuprofen, indomethacin, patent ductus arteriosus, pharmacodynamics, pharmacokinetics, prostaglandin synthesis inhibitors, TREATMENT, Cochrane metaanalysis, development, PDA closure.
Current Clinical Pharmacology
Title:Pharmacological Management of PDA: Oral Versus Intravenous Medications
Volume: 7 Issue: 4
Author(s): Gamze Demirel, Omer Erdeve and Ugur Dilmen
Affiliation:
Keywords: Ibuprofen, indomethacin, patent ductus arteriosus, pharmacodynamics, pharmacokinetics, prostaglandin synthesis inhibitors, TREATMENT, Cochrane metaanalysis, development, PDA closure.
Abstract: Patent ductus arteriosus is a common problem in very low birth weight infants. Prostaglandin synthesis inhibitors such as indomethacin and ibuprofen are widely used preferred medications for ductal closure but the question of which one should be preferred is controversial. There are some studies in the literature comparing their pharmacokinetics, efficacy, side effects and long-term outcomes. In this review we aimed to focus on prostaglandin synthesis inhibitors with their pharmacodynamic and pharmacokinetic in relation to oral and intravenous forms. Oral ibuprofen seems to be an effective and cheap alternative to the intravenous forms. Studies in extremely low birth weight infants that also evaluate the neurodevelopment will clarify its use.
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Cite this article as:
Demirel Gamze, Erdeve Omer and Dilmen Ugur, Pharmacological Management of PDA: Oral Versus Intravenous Medications, Current Clinical Pharmacology 2012; 7 (4) . https://dx.doi.org/10.2174/157488412803305830
DOI https://dx.doi.org/10.2174/157488412803305830 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
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