Abstract
Biodegradable polymeric nanofibrosus meshes have emerged as a choice of scaffolds for cells to attach and grow as they mimic closely the nanoscale morphology of native extracellular proteins and promote cell-growth. Electrospun fibrous nanocomposite scaffolds of biodegradable synthetic polymer polycaprolactone (PCL) with surface modified carbon nanofibers (mCNFs) were successfully fabricated using the electrostatic co-spinning process. Structural and morphological properties of the nanofibrous composite scaffolds were characterized using, SEM, TEM, TGA and XRD. Microscopic analyses showed bead-free nanofibrous morphology with the presence of mCNFs in the electrospun scaffolds. The overall scaffolds’ crystallinity and degree of orientation were assessed using XRD. The mechanical properties of the electrospun scaffolds as evaluated with tensile test, showed a marked increase in strength and stiffness with nanofiber alignment and with addition of mCNFs (0.1 and 0.5 wt %). Human mesenchymal stem cells (hMSCs) cultured onto PCL/mCNFs scaffold showed successful attachment and spreading of the cells.
Keywords: Carbon nanofiber, polycaprolactone, electrospinning, nanofiber scaffolds.
Current Nanoscience
Title:Carbon Nanofiber Reinforced Polycaprolactone Fibrous Meshes by Electrostatic Co-spinning
Volume: 8 Issue: 5
Author(s): Himani D. Deshpande, Derrick R. Dean, Vinoy Thomas, William C. Clem, Moncy V. Jose, Elijah Nyairo and Manoj Mishra
Affiliation:
Keywords: Carbon nanofiber, polycaprolactone, electrospinning, nanofiber scaffolds.
Abstract: Biodegradable polymeric nanofibrosus meshes have emerged as a choice of scaffolds for cells to attach and grow as they mimic closely the nanoscale morphology of native extracellular proteins and promote cell-growth. Electrospun fibrous nanocomposite scaffolds of biodegradable synthetic polymer polycaprolactone (PCL) with surface modified carbon nanofibers (mCNFs) were successfully fabricated using the electrostatic co-spinning process. Structural and morphological properties of the nanofibrous composite scaffolds were characterized using, SEM, TEM, TGA and XRD. Microscopic analyses showed bead-free nanofibrous morphology with the presence of mCNFs in the electrospun scaffolds. The overall scaffolds’ crystallinity and degree of orientation were assessed using XRD. The mechanical properties of the electrospun scaffolds as evaluated with tensile test, showed a marked increase in strength and stiffness with nanofiber alignment and with addition of mCNFs (0.1 and 0.5 wt %). Human mesenchymal stem cells (hMSCs) cultured onto PCL/mCNFs scaffold showed successful attachment and spreading of the cells.
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Cite this article as:
D. Deshpande Himani, R. Dean Derrick, Thomas Vinoy, C. Clem William, V. Jose Moncy, Nyairo Elijah and Mishra Manoj, Carbon Nanofiber Reinforced Polycaprolactone Fibrous Meshes by Electrostatic Co-spinning, Current Nanoscience 2012; 8 (5) . https://dx.doi.org/10.2174/157341312802884409
DOI https://dx.doi.org/10.2174/157341312802884409 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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