Abstract
The free-radical graft polymerization of methacrylic acid onto surface activated nano silica particles was studied experimentally. Activated silica nanoparticle were modified using different concentration of 3-Chloropropyltrimethoxysilane (3-CTMS) to load the Chlor group by bonding with the organic functional group contained in 4-hydroxybenzoic acid (4-HBA). The carboxyl group of 4-HBA was then converted to vinyl ester group by reacting nano silica-bound benzoic acid (NSBA) and vinyl acetate as an acylating agent in the presence of catalyst. Methacrylic-type nano composites were synthesized by free radical copolymerization of methacrylic acid and vinyl ester derivative of modified nano silica. The nano composites were characterized by the FTIR and SEM techniques. The equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Naproxen was entrapped in the as-prepared nano composites and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4).
Keywords: 4-hydroxybenzoic acid, nano-composites, naproxen, oral drug delivery, pH-sensitive.
Current Nanoscience
Title:Synthesis and Characterization of Novel pH-sensitive Nano Composites for Oral Drug Delivery
Volume: 8 Issue: 5
Author(s): Mehrdad Mahkam
Affiliation:
Keywords: 4-hydroxybenzoic acid, nano-composites, naproxen, oral drug delivery, pH-sensitive.
Abstract: The free-radical graft polymerization of methacrylic acid onto surface activated nano silica particles was studied experimentally. Activated silica nanoparticle were modified using different concentration of 3-Chloropropyltrimethoxysilane (3-CTMS) to load the Chlor group by bonding with the organic functional group contained in 4-hydroxybenzoic acid (4-HBA). The carboxyl group of 4-HBA was then converted to vinyl ester group by reacting nano silica-bound benzoic acid (NSBA) and vinyl acetate as an acylating agent in the presence of catalyst. Methacrylic-type nano composites were synthesized by free radical copolymerization of methacrylic acid and vinyl ester derivative of modified nano silica. The nano composites were characterized by the FTIR and SEM techniques. The equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Naproxen was entrapped in the as-prepared nano composites and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4).
Export Options
About this article
Cite this article as:
Mahkam Mehrdad, Synthesis and Characterization of Novel pH-sensitive Nano Composites for Oral Drug Delivery, Current Nanoscience 2012; 8 (5) . https://dx.doi.org/10.2174/157341312802884490
DOI https://dx.doi.org/10.2174/157341312802884490 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Advanced Nanotechnology in Forensic Science: Revolutionizing Fingerprint Identification and Crime Scene Analysis
This special issue aims to provide a comprehensive exploration of the innovative fusion between nanotechnology and forensic science. It aspires to bridge the gap between traditional investigative techniques and cutting-edge nanoscale applications, envisioning a paradigm shift in forensic analysis. By compiling the expertise of multidisciplinary experts, the book's objectives include ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Nanotechnology: Enhancing Efficiency and Safety in Environmental Pollution Remediation
This special issue delves into the transformative role of nanotechnology in addressing pressing environmental challenges. Nanomaterials, armed with their unique properties, are at the forefront of combating water contamination by removing heavy metals, pesticides, and even nanoplastics from aquatic ecosystems. In the realm of soil remediation, nanotechnology is revitalizing contaminated ...read more
Related Journals
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fangchinoline, an Extract of the <i>Stephania tetrandra</i> S. Moore Root, Promoted
Oxidative Stress-induced DNA Damage and Apoptosis and Inhibited Akt
Signaling in Jurkat T Cells
Current Molecular Pharmacology Prolyl-Specific Peptidases and Their Inhibitors in Biological Processes
Current Chemical Biology Acetylenic Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Chemoinformatics Approaches for Traditional Chinese Medicine Research and Case Application in Anticancer Drug Discovery
Current Drug Discovery Technologies Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells
Current Medicinal Chemistry C-KIT Signaling in Cancer Treatment
Current Pharmaceutical Design Arylurea Derivatives: A Class of Potential Cancer Targeting Agents
Current Topics in Medicinal Chemistry Anticancer Drug-Induced Immunomodulation and Cancer Therapeutics
Current Cancer Therapy Reviews Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours
Current Drug Discovery Technologies The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy
Current Pharmaceutical Design Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women
Current HIV Research Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents
Current Cancer Drug Targets Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II)
Anti-Cancer Agents in Medicinal Chemistry p-Sulfonic Acid Calix[n]arene Catalyzed Synthesis of Bioactive Heterocycles: A Review
Current Organic Chemistry Research Progress in Flavonoids as Potential Anticancer Drug Including Synergy with Other Approaches
Current Topics in Medicinal Chemistry Natural Products Containing Olefinic Bond: Important Substrates for Semi-synthetic Modification Towards Value Addition
Current Organic Chemistry Garlic-Derived Allyl Sulfides in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry An Overview of Conjugated Linoleic Acid: Microbial Production and Application
Mini-Reviews in Medicinal Chemistry Opinion Paper Whatever It Takes
Current Nutrition & Food Science In-Gel Protein Phosphatase Assays and Other Useful Methods for the Detection of Protein Phosphatase Activities
Anti-Cancer Agents in Medicinal Chemistry