Abstract
In this review we explore and integrate the knowledge of the plausible pharmacological targets that could explain the new application for the well known semi-synthetic, tetracycline-derivate minocycline as a cytoprotective drug. In doing so, we will analyze the possible mechanisms to elucidate the potential cytoprotective properties of minocycline. We address its anti-oxidant action ranging from its structure to its capacity to modulate the expression of oxidant-related enzymes such as nitric oxide synthase. The pharmacological targets responsible for its anti-inflammatory effects are surveyed. The effects of this antibiotic are making its marks on intracellular pathways related to neurodegenerative processes such as mitochondrially-mediated apoptosis, including minocycline-modulated effects on the expression of apoptotic proteins. Finally, we will explore the effects of minocycline on metalloproteinases, enzymes implicated in the modulation of cerebrovascular post-ischemic oxidative reperfusion injury, and new targets. In conclusion, we shed new light on the shadowy controversy of minocyclines potential cytoprotective mechanisms and targets of action.
Keywords: Anti-inflammatory, anti-oxidant, apoptosis, cytoprotection, minocycline, mitochondria, modulation of the expression of anti-apoptotic proteins, reactive oxygen species
Current Drug Delivery
Title: Minocycline and Cytoprotection: Shedding New Light on a Shadowy Controversy
Volume: 4 Issue: 3
Author(s): J. Jordan, F.J. Fernandez-Gomez, M. Ramos, I. Ikuta, N. Aguirre and M.F. Galindo
Affiliation:
Keywords: Anti-inflammatory, anti-oxidant, apoptosis, cytoprotection, minocycline, mitochondria, modulation of the expression of anti-apoptotic proteins, reactive oxygen species
Abstract: In this review we explore and integrate the knowledge of the plausible pharmacological targets that could explain the new application for the well known semi-synthetic, tetracycline-derivate minocycline as a cytoprotective drug. In doing so, we will analyze the possible mechanisms to elucidate the potential cytoprotective properties of minocycline. We address its anti-oxidant action ranging from its structure to its capacity to modulate the expression of oxidant-related enzymes such as nitric oxide synthase. The pharmacological targets responsible for its anti-inflammatory effects are surveyed. The effects of this antibiotic are making its marks on intracellular pathways related to neurodegenerative processes such as mitochondrially-mediated apoptosis, including minocycline-modulated effects on the expression of apoptotic proteins. Finally, we will explore the effects of minocycline on metalloproteinases, enzymes implicated in the modulation of cerebrovascular post-ischemic oxidative reperfusion injury, and new targets. In conclusion, we shed new light on the shadowy controversy of minocyclines potential cytoprotective mechanisms and targets of action.
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Cite this article as:
J. Jordan , F.J. Fernandez-Gomez , M. Ramos , I. Ikuta , N. Aguirre and M.F. Galindo , Minocycline and Cytoprotection: Shedding New Light on a Shadowy Controversy, Current Drug Delivery 2007; 4 (3) . https://dx.doi.org/10.2174/156720107781023938
DOI https://dx.doi.org/10.2174/156720107781023938 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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