Abstract
Given the variable protective efficacy provided by Mycobacterium bovis BCG (Bacillus Calmette-Guerin), there is a concerted effort worldwide to develop better vaccines that could be used to reduce the burden of tuberculosis. Recombinant BCG (rBCG) are vaccine candidates that offer some potential in this area. In this paper, we will discuss the molecular methods used to generate rBCG, and the results obtained with some of these new vaccines as compared with the conventional BCG vaccine in diverse animal models. Tuberculosis vaccine candidates based on rBCG are promising candidates, and some of them are now being tested in clinical trials.
Keywords: Immunogenicity, preclinical, animal models, cytokine expression, antigen secretion
Current Molecular Medicine
Title: Recombinant BCG Vaccine Candidates
Volume: 7 Issue: 4
Author(s): Rogelio Hernandez-Pando, Mauricio Castanon, Clara Espitia and Yolanda Lopez-Vidal
Affiliation:
Keywords: Immunogenicity, preclinical, animal models, cytokine expression, antigen secretion
Abstract: Given the variable protective efficacy provided by Mycobacterium bovis BCG (Bacillus Calmette-Guerin), there is a concerted effort worldwide to develop better vaccines that could be used to reduce the burden of tuberculosis. Recombinant BCG (rBCG) are vaccine candidates that offer some potential in this area. In this paper, we will discuss the molecular methods used to generate rBCG, and the results obtained with some of these new vaccines as compared with the conventional BCG vaccine in diverse animal models. Tuberculosis vaccine candidates based on rBCG are promising candidates, and some of them are now being tested in clinical trials.
Export Options
About this article
Cite this article as:
Hernandez-Pando Rogelio, Castanon Mauricio, Espitia Clara and Lopez-Vidal Yolanda, Recombinant BCG Vaccine Candidates, Current Molecular Medicine 2007; 7 (4) . https://dx.doi.org/10.2174/156652407780831610
DOI https://dx.doi.org/10.2174/156652407780831610 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Functional PLGA NPs for Oral Drug Delivery: Recent Strategies and Developments
Mini-Reviews in Medicinal Chemistry Perspectives on Tuberculosis Pathogenesis and Discovery of Anti- Tubercular Drugs
Current Medicinal Chemistry Patent Selections
Recent Patents on Nanomedicine Clinical Case of Organic Pseudopsychopathic Disorder in a Teenager in Terms of Differential Diagnostics with Childhood Schizophrenia
Current Psychiatry Research and Reviews Fast and Efficient One-Pot Three-Component Synthesis of Some 1,2,3,4- Tetrahydro-6-methyl-N-phenyl-5-pyrimidinecarboxamide Derivatives via Biginelli Condensation Reaction
Letters in Organic Chemistry Editorial [ Hot Topic: Potential Targets for the Rational Design of Antiparasitic Drugs (Executive Editor: Mahmoud H. el Kouni) ]
Current Pharmaceutical Design Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents
Current Medicinal Chemistry Structure and Function of L,D- and D,D-Transpeptidase Family Enzymes from Mycobacterium tuberculosis
Current Medicinal Chemistry Natural Endoperoxides as Drug Lead Compounds
Current Medicinal Chemistry Acetate Kinase (AcK) is Essential for Microbial Growth and Betel-derived Compounds Potentially Target AcK, PhoP and MDR Proteins in M. tuberculosis, V. cholerae and Pathogenic E. coli: An in silico and in vitro Study
Current Topics in Medicinal Chemistry A Brief Study on Drug Repurposing: New Way of Boosting Drug Discovery
Letters in Drug Design & Discovery A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy.
Recent Patents on Anti-Infective Drug Discovery Meet Our Editorial Board Member:
Current Medicinal Chemistry Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist
Current Topics in Medicinal Chemistry Synthesis, In Vitro Evaluations and Structure-Activity Assessment of Pyrrole Hydrazones as Potential Tuberculostatics
Letters in Drug Design & Discovery Anti-TNF Antibodies in Inflammatory Bowel Disease: Do We Finally Know How it Works?
Current Drug Targets Occupational Respiratory Pathology in Russia: Current Trends and Challenges
Current Respiratory Medicine Reviews Controlling Pathogenic Gram-Negative Bacteria by Interfering with Their Biofilm Formation
Drug Design Reviews - Online (Discontinued) The Medicinal Chemistry of Genus <i>Aralia</i>
Current Topics in Medicinal Chemistry Adolescents Attitudes Toward Vaccinations: A Systematic Review
Current Pediatric Reviews