Abstract
Ulcerative colitis is known to cause damage to the liver tissue. Although synthetic and natural substances have been used to prevent liver damage in colitis, little success has been achieved so far. In this study rats were given 120 mg/kg of trinitrobenzene sulfonic acid (TNBS) in order to induce colitis. Protective effects of lycopene and N-Nitro-LArginine Methyl Ester (L-NAME) on oxidative stress and liver damage in colitis were assessed. 91 male Sprague Dawley rats were used in this study. These rats were divided into 12 groups, each consisting of 7 rats, apart from the control group. 1ml of saline was administrated intraperitoneally (i.p) to the rats in the control group, while all the other groups were given TNBS dissolved in 50% ethanol through the intrarectal tract on the first day of the experiment. Groups 1, 2 and 3 were labeled as TNBS groups. 24 hours after the administration of TNBS, rats in groups 4, 5 and 6 were given LNAME, the ones in groups 7, 8, 9 given 1ml/kg olive oil. The remaining groups (10, 11 and 12) were given 5 mg/kg of lycopene i.p. Histological and biochemical analyses were carried out. In liver, tissue damage parameters like edema, sinusoidal dilatation, necrosis, vacuolization and accumulation of inflammatory cells were observed. Evaluation of serum aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) levels, as well as histopathological findings of the liver tissue, show that lycopene has a protective effect upon liver damage due to colitis, and that lycopene is more beneficial to preventing oxidative stress than are olive oil and L-NAME, a synthetic antioxidant substance.
Keywords: Antioxidant, colitis, hepatoprotectivity, hepatotoxicity, L-NAME, lycopene, rat, TNBS
Current Drug Therapy
Title:Lycopene Protects Liver Against Ulcerative Colitis
Volume: 7 Issue: 1
Author(s): Mustafa Cengiz, Yılmaz Altuner, Varol Sahinturk, Hilmi Ozden, Hakan Senturk, Gokhan Bayramoglu, Bilge Ozkal, Ahmet Musmul, Dilek Burukoglu, Rifat Ertekin, Ilknur Kulcanay Sahin and Adnan Ayhanci
Affiliation:
Keywords: Antioxidant, colitis, hepatoprotectivity, hepatotoxicity, L-NAME, lycopene, rat, TNBS
Abstract: Ulcerative colitis is known to cause damage to the liver tissue. Although synthetic and natural substances have been used to prevent liver damage in colitis, little success has been achieved so far. In this study rats were given 120 mg/kg of trinitrobenzene sulfonic acid (TNBS) in order to induce colitis. Protective effects of lycopene and N-Nitro-LArginine Methyl Ester (L-NAME) on oxidative stress and liver damage in colitis were assessed. 91 male Sprague Dawley rats were used in this study. These rats were divided into 12 groups, each consisting of 7 rats, apart from the control group. 1ml of saline was administrated intraperitoneally (i.p) to the rats in the control group, while all the other groups were given TNBS dissolved in 50% ethanol through the intrarectal tract on the first day of the experiment. Groups 1, 2 and 3 were labeled as TNBS groups. 24 hours after the administration of TNBS, rats in groups 4, 5 and 6 were given LNAME, the ones in groups 7, 8, 9 given 1ml/kg olive oil. The remaining groups (10, 11 and 12) were given 5 mg/kg of lycopene i.p. Histological and biochemical analyses were carried out. In liver, tissue damage parameters like edema, sinusoidal dilatation, necrosis, vacuolization and accumulation of inflammatory cells were observed. Evaluation of serum aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) levels, as well as histopathological findings of the liver tissue, show that lycopene has a protective effect upon liver damage due to colitis, and that lycopene is more beneficial to preventing oxidative stress than are olive oil and L-NAME, a synthetic antioxidant substance.
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Cengiz Mustafa, Altuner Yılmaz, Sahinturk Varol, Ozden Hilmi, Senturk Hakan, Bayramoglu Gokhan, Ozkal Bilge, Musmul Ahmet, Burukoglu Dilek, Ertekin Rifat, Kulcanay Sahin Ilknur and Ayhanci Adnan, Lycopene Protects Liver Against Ulcerative Colitis, Current Drug Therapy 2012; 7 (1) . https://dx.doi.org/10.2174/157488512800389227
DOI https://dx.doi.org/10.2174/157488512800389227 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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