Abstract
Acquired immunodeficiency syndrome (AIDS) is one of the most important public health problems, affecting many people every day. This syndrome is caused by the human immunodeficiency virus (HIV) and the HIV-1 protease plays an essential role by promoting virus maturation and thus infecting new cells. The HIV-1 protease is one of the main targets for anti-HIV drug therapy. The present work is a literature survey of plant extracts whose activity has been studied on HIV-1 protease. Here we list 275 species of medicinal plants, distributed in 99 families, with their place of origin, part used, type of extract, concentration and activity. We aim with this work to provide data that could be used in the research and development of new therapeutic agents for AIDS treatment.
Keywords: Review, natural products, plants, AIDS, HIV-1 Protease, Anti-HIV drugs, Plant Extracts, Acquired immunodeficiency syndrome, human immunodeficiency virus, anti-HIV drug therapy, CCR5, CXCR4, CD4 receptors, aspartyl-protease family, non-infectious virions, AIDS-chemotherapy, allergy, malaria, osteoporosis, hyperglycemia, Andrographis paniculata, Baphicacanthus cusia, Actinidia arguta, Alisma plantago-aquatica, Crinum macowani Baker, Rhus acuminata DC, Rhus javanica L, Magnolia genus, M. fargesii, M. obovata, M. oficinalis, Terminalia species, T. belerica, T. chebula, Geum japonicum, Punica granatum, Rhus javanica, T. arjuna, Woodwardia orientalis, W. unigemmata
Current HIV Research
Title: Effects of Plant Extracts on HIV-1 Protease
Volume: 8 Issue: 7
Author(s): Jaime Ribeiro Filho, Heloina de Sousa Falcao, Leonia Maria Batista, Jose Maria Barbosa Filho and Marcia Regina Piuvezam
Affiliation:
Keywords: Review, natural products, plants, AIDS, HIV-1 Protease, Anti-HIV drugs, Plant Extracts, Acquired immunodeficiency syndrome, human immunodeficiency virus, anti-HIV drug therapy, CCR5, CXCR4, CD4 receptors, aspartyl-protease family, non-infectious virions, AIDS-chemotherapy, allergy, malaria, osteoporosis, hyperglycemia, Andrographis paniculata, Baphicacanthus cusia, Actinidia arguta, Alisma plantago-aquatica, Crinum macowani Baker, Rhus acuminata DC, Rhus javanica L, Magnolia genus, M. fargesii, M. obovata, M. oficinalis, Terminalia species, T. belerica, T. chebula, Geum japonicum, Punica granatum, Rhus javanica, T. arjuna, Woodwardia orientalis, W. unigemmata
Abstract: Acquired immunodeficiency syndrome (AIDS) is one of the most important public health problems, affecting many people every day. This syndrome is caused by the human immunodeficiency virus (HIV) and the HIV-1 protease plays an essential role by promoting virus maturation and thus infecting new cells. The HIV-1 protease is one of the main targets for anti-HIV drug therapy. The present work is a literature survey of plant extracts whose activity has been studied on HIV-1 protease. Here we list 275 species of medicinal plants, distributed in 99 families, with their place of origin, part used, type of extract, concentration and activity. We aim with this work to provide data that could be used in the research and development of new therapeutic agents for AIDS treatment.
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Cite this article as:
Ribeiro Filho Jaime, de Sousa Falcao Heloina, Maria Batista Leonia, Maria Barbosa Filho Jose and Regina Piuvezam Marcia, Effects of Plant Extracts on HIV-1 Protease, Current HIV Research 2010; 8 (7) . https://dx.doi.org/10.2174/157016210793499204
DOI https://dx.doi.org/10.2174/157016210793499204 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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In the era of combined antiretroviral therapy (cART), the incidence of lymphoma among people living with HIV (PLWH) surpassed Kaposi's sarcoma in 2011, becoming the most common AIDS-defining malignancy. The annual incidence rate ranges approximately from 100 to 300 per 100,000 individuals with HIV infection as the population denominator, which ...read more
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