Abstract
Pulmonary complications of AIDS are one of the major causes of morbidity and mortality in HIVinfected individuals, and are often direct indicators of enhanced progression to an AIDS-defining illness. HIV can be detected in the lung during asymptomatic disease, as well as during the advanced stages of AIDS. With prolonged survival of HIV-infected patients, non-infectious pulmonary complications are becoming more common and can lead to respiratory compromise and failure. The pathogenesis of non-infectious pulmonary complications, following HIV infection is not fully understood, and the role that HIV-induced immunosuppression plays in the development of these complications is not known. In this review, we will discuss non-infectious pulmonary complications of HIV infection, focusing on HIV-associated malignancies of the lung, inflammatory disorders, pulmonary hypertension and the effect of antiretroviral therapy on the incidence of these diseases. The possible role that HIV plays in the pathogenesis of these pulmonary disorders is also addressed.
Keywords: hiv, pulmonary complications, lung malignancies, inflammatory disorders
Current HIV Research
Title: Is HIV Involved in the Pathogenesis of Non-Infectious Pulmonary Complications in Infected Patients?
Volume: 1 Issue: 4
Author(s): Georgette D. Kanmogne, Ronald C. Kennedy and Paula Grammas
Affiliation:
Keywords: hiv, pulmonary complications, lung malignancies, inflammatory disorders
Abstract: Pulmonary complications of AIDS are one of the major causes of morbidity and mortality in HIVinfected individuals, and are often direct indicators of enhanced progression to an AIDS-defining illness. HIV can be detected in the lung during asymptomatic disease, as well as during the advanced stages of AIDS. With prolonged survival of HIV-infected patients, non-infectious pulmonary complications are becoming more common and can lead to respiratory compromise and failure. The pathogenesis of non-infectious pulmonary complications, following HIV infection is not fully understood, and the role that HIV-induced immunosuppression plays in the development of these complications is not known. In this review, we will discuss non-infectious pulmonary complications of HIV infection, focusing on HIV-associated malignancies of the lung, inflammatory disorders, pulmonary hypertension and the effect of antiretroviral therapy on the incidence of these diseases. The possible role that HIV plays in the pathogenesis of these pulmonary disorders is also addressed.
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Kanmogne D. Georgette, Kennedy C. Ronald and Grammas Paula, Is HIV Involved in the Pathogenesis of Non-Infectious Pulmonary Complications in Infected Patients?, Current HIV Research 2003; 1 (4) . https://dx.doi.org/10.2174/1570162033485177
DOI https://dx.doi.org/10.2174/1570162033485177 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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