Abstract
To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, L ys tRNA3 . The annealing of L ys tRNA3 to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annealing is mediated by a viral factor, the nucleocapsid protein. This protein has been studied for a long while to define the role of its different sub-domains and their mode of action. Only recently, a consensus view seems to emerge. The structure of the initiation complex, is still discussed. The goal of this review is to clarify what is known about the formation and the structure of the tRNA/viral RNA complex and the role of the nucleocapsid protein from a structural point of view.
Keywords: reverse transcription, primer trnalys3, trnalys3 annealing to viral rna, nucleocapsid protein
Current HIV Research
Title: Structural Bases of the Annealing of Primer Lys tRNA to the HIV-1 Viral RNA
Volume: 3 Issue: 2
Author(s): Carine Tisne
Affiliation:
Keywords: reverse transcription, primer trnalys3, trnalys3 annealing to viral rna, nucleocapsid protein
Abstract: To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, L ys tRNA3 . The annealing of L ys tRNA3 to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annealing is mediated by a viral factor, the nucleocapsid protein. This protein has been studied for a long while to define the role of its different sub-domains and their mode of action. Only recently, a consensus view seems to emerge. The structure of the initiation complex, is still discussed. The goal of this review is to clarify what is known about the formation and the structure of the tRNA/viral RNA complex and the role of the nucleocapsid protein from a structural point of view.
Export Options
About this article
Cite this article as:
Tisne Carine, Structural Bases of the Annealing of Primer Lys tRNA to the HIV-1 Viral RNA, Current HIV Research 2005; 3 (2) . https://dx.doi.org/10.2174/1570162053506919
DOI https://dx.doi.org/10.2174/1570162053506919 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers