Abstract
Caveolae are highly enriched in numerous membrane-bound proteins and caveolin-1 is their major component. Caveolae and caveolin proteins are involved in a variety of cellular processes including lipid homeostasis, endocytosis, signal transduction, and tumorigenesis. Breast cancer is one of the most common cancers in women throughout the world. Clinical studies have shown that the correlation of caveolin-1 expression with tumor progression varies with tumor type. The data presented here extend the findings that caveolin-1 suppresses breast cancer but there are controversial studies. The potential function of caveolin-1 in scaffolding signaling factors also demonstrates the importance of its expression control and modulation, correlating with physiological or pathological conditions. Based on current research, this review presents the current understanding of their function and the involvement of caveolin-1 in breast cancer pathogenesis.
Keywords: Caveolin-1, breast cancer, caveolae, membrane-bound proteins, lipid homeostasis, endocytosis, signal transduction, tumorigenesis, Clinical studies, little caves
Mini-Reviews in Medicinal Chemistry
Title: Caveolin Involvement and Modulation in Breast Cancer
Volume: 11 Issue: 13
Author(s): M. N. Aoki, M. K. Amarante, J. M.M. Oda and M. A.E. Watanabe
Affiliation:
Keywords: Caveolin-1, breast cancer, caveolae, membrane-bound proteins, lipid homeostasis, endocytosis, signal transduction, tumorigenesis, Clinical studies, little caves
Abstract: Caveolae are highly enriched in numerous membrane-bound proteins and caveolin-1 is their major component. Caveolae and caveolin proteins are involved in a variety of cellular processes including lipid homeostasis, endocytosis, signal transduction, and tumorigenesis. Breast cancer is one of the most common cancers in women throughout the world. Clinical studies have shown that the correlation of caveolin-1 expression with tumor progression varies with tumor type. The data presented here extend the findings that caveolin-1 suppresses breast cancer but there are controversial studies. The potential function of caveolin-1 in scaffolding signaling factors also demonstrates the importance of its expression control and modulation, correlating with physiological or pathological conditions. Based on current research, this review presents the current understanding of their function and the involvement of caveolin-1 in breast cancer pathogenesis.
Export Options
About this article
Cite this article as:
N. Aoki M., K. Amarante M., M.M. Oda J. and A.E. Watanabe M., Caveolin Involvement and Modulation in Breast Cancer, Mini-Reviews in Medicinal Chemistry 2011; 11 (13) . https://dx.doi.org/10.2174/138955711797655344
DOI https://dx.doi.org/10.2174/138955711797655344 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Drugs and mitochondria
Mitochondria play a central role in the life and death of cells. They are not merely the center for energy metabolism but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signaling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer’s, Parkinson’s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Small Molecule Protein-Protein Inhibitors for the p53-MDM2 Interaction
Current Topics in Medicinal Chemistry An Update on MDMX and Dual MDM2/X Inhibitors
Current Topics in Medicinal Chemistry Discovering Tumor Suppressor Genes Through Genome-Wide Copy Number Analysis
Current Genomics Radionuclides Used in Nuclear Medicine Therapy – From Production to Dosimetry
Current Medical Imaging Targeted Multimodal Liposomes for Nano-delivery and Imaging: An Avenger for Drug Resistance and Cancer
Current Gene Therapy Optimization of Performance Variables of Exemestane Nanosuspension Using Box-Behnken Design to Improve Dissolution and Oral Bioavailability
Current Drug Delivery Free Flap Head and Neck Reconstruction After Cancer Therapy: Current State of the Art
Current Cancer Therapy Reviews Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity
Current Protein & Peptide Science Recent Updates on Biological Activities of Oxadiazoles
Mini-Reviews in Medicinal Chemistry The Function and Regulation of BMP6 in Various Kinds of Stem Cells
Current Pharmaceutical Design Pharmacological Intervention of Cyclooxygenase-2 and 5-Lipoxygenase Pathways. Impact on Inflammation and Cancer
Current Pharmaceutical Design Small Molecule Integrin Antagonists in Cancer Therapy
Mini-Reviews in Medicinal Chemistry Treatment Approaches in Elderly Patients with Head and Neck Cancer
Anti-Cancer Agents in Medicinal Chemistry Radiation-Induced Lung Injury Following Therapy for Thoracic Malignancy
Current Respiratory Medicine Reviews Oxidative Stress in Tumor Angiogenesis - Therapeutic Targets
Current Pharmaceutical Design Osteonecrosis of the Jaw and Angiogenesis inhibitors: A Revival of a Rare but Serous Side Effect
Current Medicinal Chemistry Zoledronic Acid -a Multiplicity of Anti-Cancer Action
Current Medicinal Chemistry The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, Including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumins
Current Organic Synthesis Synthetic Androgens as Designer Supplements
Current Neuropharmacology Virotherapy as An Approach Against Cancer Stem Cells
Current Gene Therapy