Abstract
The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.
Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release
Current Drug Delivery
Title: PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug
Volume: 4 Issue: 1
Author(s): P. Vijayaraj Kumar, Hrushikesh Agashe, Tathagata Dutta and Narendra K. Jain
Affiliation:
Keywords: Dendrimers, PEGylation, micelles, rifampicin, prolonged release
Abstract: The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non- PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.
Export Options
About this article
Cite this article as:
Vijayaraj Kumar P., Agashe Hrushikesh, Dutta Tathagata and Jain K. Narendra, PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug, Current Drug Delivery 2007; 4 (1) . https://dx.doi.org/10.2174/156720107779314794
DOI https://dx.doi.org/10.2174/156720107779314794 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advancements in Robotic and AI-based Drug Discovery and Delivery for Neurological Disorders
Neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumors, pose significant challenges in drug delivery due to the blood-brain barrier's intricate structure and the complexity of neuronal networks. Traditional drug delivery methods often fall short in reaching therapeutic concentrations within the central nervous system, limiting treatment efficacy and ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Nanoemulsions in cancer therapy
Solid tumors are characterized by leaky vascular structure, defective angiogenesis and high interstitial fluid load, providing opportunities for nanoparticles to preferentially exudate and be retained in tumors. This phenomenon is commonly referred to as the enhanced permeability and retention (EPR) effect, which is considered to be an important reason why ...read more
Pioneering Drug Delivery Strategies for Enhanced Cancer Immunotherapies
The landscape of cancer treatment has been fundamentally transformed by the advent of immunotherapy, a modality that harnesses the body's immune system to recognize and combat malignant cells. Despite its remarkable successes, the full potential of cancer immunotherapy is yet to be realized, largely due to limitations in targeted delivery, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Diagnosis of Systemic Lupus Erythematosus in an Unusual Presentation: What a Primary Care Physician Should Know
Current Rheumatology Reviews Recent Patents and Advances on Anti - Tuberculosis Drug Delivery and Formulations
Recent Patents on Drug Delivery & Formulation Comparison of Pharmacokinetic Profiles of Moxifloxacin in Caesarean versus Non-Pregnant Sectioned Women by Fully Validated HPLC with Fluorescence Detection
Combinatorial Chemistry & High Throughput Screening Nanomedicine for Gene Delivery for the Treatment of Cardiovascular Diseases
Current Gene Therapy Potential Triazole-based Molecules for the Treatment of Neglected Diseases
Current Medicinal Chemistry Antimicrobial Activity of Phenolics and Glucosinolate Hydrolysis Products and their Synergy with Streptomycin against Pathogenic Bacteria
Medicinal Chemistry Detection of Non-Tuberculosis Mycobacteria by Real Time PCR
Anti-Infective Agents A Perspective on Clinical Islet Transplantation: Past, Present and Developments for Future
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) CoMFA Study, Syntheses, Antitubercular and Anticancer Activity of Some Novel 1,4-Dihydropyridines
Letters in Drug Design & Discovery Anti-Infective Protective Properties of S100 Calgranulins
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry QSAR as a Random Event: Selecting of the Molecular Structure for Potential Anti-tuberculosis Agents
Anti-Infective Agents Salmonella as Live Trojan Horse for Vaccine Development and Cancer Gene Therapy
Current Gene Therapy Inflammatory Syndrome in Chronic Kidney Disease: Pathogenesis and Influence on Outcomes
Inflammation & Allergy - Drug Targets (Discontinued) Editorial: An Emerging Immunogenomics and Computational Approach for Peptide Vaccinology: Rational Design of Peptide Vaccines
Current Computer-Aided Drug Design Iron Acquisition Pathways as Targets for Antitubercular Drugs
Current Medicinal Chemistry Synthesis and Biological Evaluation of Hybrid 1,5- and 2,5-Disubstituted Indoles as Potentially New Antitubercular Agents
Medicinal Chemistry Modern Therapeutic Strategies for Autoimmune Diseases
Current Pharmaceutical Design New Patentable Use of an Old Neuroleptic Compound Thioridazine to Combat Tuberculosis: A Gene Regulation Perspective
Recent Patents on Anti-Infective Drug Discovery Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs
Current Topics in Medicinal Chemistry Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity
Letters in Drug Design & Discovery