Abstract
Resistance to undergo apoptosis is a characteristic feature of human malignancies, including childhood leukemia. Apoptosis, or programmed cell death, is the most common intrinsic cell death programs that plays a critical role in maintaining tissue homeostasis, for example in the hematopoietic system. Accordingly, too little apoptosis can promote tumor formation and also treatment resistance, since the anti-leukemic activity of most current treatment approaches, i.e. chemo-, radio- or immunotherapy critically depends on intact apoptosis signaling pathways in leukemia cells. Thus, defective apoptosis programs confer resistance to anti-leukemic therapy. The elucidation of the signaling components mediating apoptosis in leukemia cells has provided multiple targets for therapeutic intervention. These targets can be exploited to develop novel treatment strategies better directed at selective intervention points in the apoptotic machinery. Several of these approaches have already been translated into a clinical application. Thus, the exploitation of apoptosis signaling pathways for leukemia therapy opens new perspectives for effective treatment protocols for childhood leukemia.
Keywords: Apoptosis, leukemia, TRAIL, IAPs, mitochondria, Signaling pathways, Bcl-2 PROTEINS, Receptor, Caspase, Bcl-2 inhibitors
Current Pediatric Reviews
Title: Exploitation of Apoptosis Pathways for Childhood Leukemia
Volume: 7 Issue: 4
Author(s): Simone Fulda
Affiliation:
Keywords: Apoptosis, leukemia, TRAIL, IAPs, mitochondria, Signaling pathways, Bcl-2 PROTEINS, Receptor, Caspase, Bcl-2 inhibitors
Abstract: Resistance to undergo apoptosis is a characteristic feature of human malignancies, including childhood leukemia. Apoptosis, or programmed cell death, is the most common intrinsic cell death programs that plays a critical role in maintaining tissue homeostasis, for example in the hematopoietic system. Accordingly, too little apoptosis can promote tumor formation and also treatment resistance, since the anti-leukemic activity of most current treatment approaches, i.e. chemo-, radio- or immunotherapy critically depends on intact apoptosis signaling pathways in leukemia cells. Thus, defective apoptosis programs confer resistance to anti-leukemic therapy. The elucidation of the signaling components mediating apoptosis in leukemia cells has provided multiple targets for therapeutic intervention. These targets can be exploited to develop novel treatment strategies better directed at selective intervention points in the apoptotic machinery. Several of these approaches have already been translated into a clinical application. Thus, the exploitation of apoptosis signaling pathways for leukemia therapy opens new perspectives for effective treatment protocols for childhood leukemia.
Export Options
About this article
Cite this article as:
Fulda Simone, Exploitation of Apoptosis Pathways for Childhood Leukemia, Current Pediatric Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339611796892355
DOI https://dx.doi.org/10.2174/157339611796892355 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mesenchymal Stem Cell as a Potential Therapeutic for Inflammatory Bowel Disease- Myth or Reality?
Current Stem Cell Research & Therapy Meet Our Editorial Board Member
Current Respiratory Medicine Reviews Physiological and Comparative Evidence Fails to Confirm an Adaptive Role for Aging in Evolution
Current Aging Science Xiaoyao Pill Improves the Affective Dysregulation of Sleep-deprived Female Mice by Inhibiting Brain Injury and Regulating the Content of Monoamine Neurotransmitter
Current Pharmaceutical Biotechnology Mining Sarcomas by Proteomics Approaches: Ewing Sarcoma on the Spotlight
Recent Patents on Biotechnology Preface
Current Pediatric Reviews The Antimitotic Potential of PARP Inhibitors, An Unexplored Therapeutic Alternative
Current Topics in Medicinal Chemistry Hardware and Software Approaches to Multi-Modality Imaging
Current Medical Imaging Nucleoside Transporter Proteins
Current Vascular Pharmacology Subject Index To Volume 2
Current Psychiatry Reviews The Role of FLT3 Kinase as an AML Therapy Target
Current Pharmaceutical Design Clinical Pharmacogenomics of Thiopurine S-methyltransferase
Current Clinical Pharmacology Evolution of Chemosensitivity and Resistance Assays as Predictors of Clinical Outcomes in Epithelial Ovarian Cancer Patients
Current Pharmaceutical Design Identification of Two Novel Mutations in the <i>ATM</i> Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing
Current Genomics Inhibition of Apoptosis in Pediatric Cancer by Survivin
Current Pediatric Reviews The Complex Airway in Childhood Asthma
Current Pediatric Reviews Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer
Current Drug Targets Nanocarriers as Prospective Approach in Effective Management of Acne Vulgaris
Micro and Nanosystems Current and Future Applications of Probiotics
Current Nutrition & Food Science Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia
Current Drug Targets