Abstract
High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.
Keywords: Glioma, stem, gene therapy, cancer, resistance, High grade, ADSC, bone morphogenetic protein, cytosine deaminase, cyclophosphamide, connexin 43, EGF, ganciclovir, mesenchymal stem cell
Mini-Reviews in Medicinal Chemistry
Title: Stem Cell-Mediated Delivery of Therapies in the Treatment of Glioma
Volume: 11 Issue: 7
Author(s): G. Frosina
Affiliation:
Keywords: Glioma, stem, gene therapy, cancer, resistance, High grade, ADSC, bone morphogenetic protein, cytosine deaminase, cyclophosphamide, connexin 43, EGF, ganciclovir, mesenchymal stem cell
Abstract: High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.
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Cite this article as:
Frosina G., Stem Cell-Mediated Delivery of Therapies in the Treatment of Glioma, Mini-Reviews in Medicinal Chemistry 2011; 11 (7) . https://dx.doi.org/10.2174/138955711795906897
DOI https://dx.doi.org/10.2174/138955711795906897 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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