Abstract
Primary malignant central nervous system (CNS) tumors only represent about 2% of all cancers. However, they are very often associated with high morbidity and mortality. Despite current standard-of-care therapy, such as surgery, irradiation, and chemotherapy, neither cure nor any toxic therapy against malignant CNS tumors has been developed so far. Nanotechnology may alter this situation. It offers a new promise for cancer diagnosis and treatment. This emerging technology, by developing and manufacturing materials using atomic and molecular elements, can provide a platform for the combination of diagnostics, therapeutics and delivery to the tumor, with subsequent monitoring of the response. This review focuses on recent developments in cancer nanotechnology with particular attention to nanoparticle systems, important tools for the improvement of drug delivery in brain tumor. The latest advances in both the research sector and in recent patents for cancer imaging and therapy are discussed.
Keywords: Cancer treatment, drug delivery, gene therapy, nanotechnology, nanoparticle, patent, Glioma vasculature, Fluorescein, Magnetofluorescent nanoprobes, Liposomes, Gold NPs, Quantum dots, Magnetic nanocrystals, Dye-loaded NPs, Immunotargeted nanoshells, SPIONs, FITC, photoacoustic computed, omography (PAT), ZnCdS, EGFR, AS1411 aptamer, Chitosan, Hydrogels, PEGylated PHDCA, spinal neoplasm, LSFV-IL12, HSV-1-tk, EpCAM, MWCNTs, Nanostructure Enhanced X-ray Therapy, CAT scan, cGMP
Recent Patents on Anti-Cancer Drug Discovery
Title: Nanotechnology Advances in Brain Tumors: The State of the Art
Volume: 6 Issue: 1
Author(s): Gloria Invernici, Silvia Cristini, Giulio Alessandri, Stefania E. Navone, Laura Canzi, Daniela Tavian, Chiara Redaelli, Francesco Acerbi and Eugenio A. Parati
Affiliation:
Keywords: Cancer treatment, drug delivery, gene therapy, nanotechnology, nanoparticle, patent, Glioma vasculature, Fluorescein, Magnetofluorescent nanoprobes, Liposomes, Gold NPs, Quantum dots, Magnetic nanocrystals, Dye-loaded NPs, Immunotargeted nanoshells, SPIONs, FITC, photoacoustic computed, omography (PAT), ZnCdS, EGFR, AS1411 aptamer, Chitosan, Hydrogels, PEGylated PHDCA, spinal neoplasm, LSFV-IL12, HSV-1-tk, EpCAM, MWCNTs, Nanostructure Enhanced X-ray Therapy, CAT scan, cGMP
Abstract: Primary malignant central nervous system (CNS) tumors only represent about 2% of all cancers. However, they are very often associated with high morbidity and mortality. Despite current standard-of-care therapy, such as surgery, irradiation, and chemotherapy, neither cure nor any toxic therapy against malignant CNS tumors has been developed so far. Nanotechnology may alter this situation. It offers a new promise for cancer diagnosis and treatment. This emerging technology, by developing and manufacturing materials using atomic and molecular elements, can provide a platform for the combination of diagnostics, therapeutics and delivery to the tumor, with subsequent monitoring of the response. This review focuses on recent developments in cancer nanotechnology with particular attention to nanoparticle systems, important tools for the improvement of drug delivery in brain tumor. The latest advances in both the research sector and in recent patents for cancer imaging and therapy are discussed.
Export Options
About this article
Cite this article as:
Invernici Gloria, Cristini Silvia, Alessandri Giulio, E. Navone Stefania, Canzi Laura, Tavian Daniela, Redaelli Chiara, Acerbi Francesco and A. Parati Eugenio, Nanotechnology Advances in Brain Tumors: The State of the Art, Recent Patents on Anti-Cancer Drug Discovery 2011; 6 (1) . https://dx.doi.org/10.2174/157489211793979990
DOI https://dx.doi.org/10.2174/157489211793979990 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biological Activities of QIAPI 1 as a Melanin Precursor and Its Therapeutic Effects in Wistar Rats Exposed to Arsenic Poisoning
Central Nervous System Agents in Medicinal Chemistry Pharmacological Targeting of the Hsp70 Chaperone
Current Topics in Medicinal Chemistry The Tumor Suppressor Gene ARF as a Sensor of Oxidative Stress
Current Molecular Medicine Big Data for Treatment Planning: Pathways and Possibilities for Smart Healthcare Systems
Current Medical Imaging The Proteolytic Activation of Angiogenic and Lymphangiogenic Growth Factors in Cancer – Its Potential Relevance for Therapeutics and Diagnostics
Current Medicinal Chemistry Therapeutic Use of Chemokines
Current Pharmaceutical Design The Role of Brain Cholesterol and its Oxidized Products in Alzheimer's Disease
Current Alzheimer Research Review of Magnetic Resonance Imaging and Post-processing for the Brain Tumor-related Epilepsy Study
Current Medical Imaging The Role for Oxidative Stress in Aberrant DNA Methylation in Alzheimer’s Disease
Current Alzheimer Research Clinical Considerations of Focal Drug Delivery in Cancer Treatment
Current Drug Delivery Glucose-6-phosphate Dehydrogenase: a Biomarker and Potential Therapeutic Target for Cancer
Anti-Cancer Agents in Medicinal Chemistry Beyond the "Lock and Key" Paradigm: Targeting Lipid Rafts to Induce the Selective Apoptosis of Cancer Cells
Current Medicinal Chemistry Metabolite Quantification in Tumours by Magnetic Resonance Spectroscopy: Objectives, Results and Perspectives
Current Medical Imaging Ultrasound-Triggered Immunotherapy for Cancer Treatment: An Update
Current Protein & Peptide Science <i>Uncaria tomentosa</i> (Willd. ex Schult.): Focus on Nutraceutical Aspects
Current Bioactive Compounds Anti-cancer Research on Arnebiae radix-derived Naphthoquinone in Recent Five Years
Recent Patents on Anti-Cancer Drug Discovery Cardiac ATP-Sensitive Potassium Channels: A Potential Target for an Anti-Ischaemic Pharmacological Strategy
Cardiovascular & Hematological Agents in Medicinal Chemistry Ligand-Targeted Liposomes for Cancer Treatment
Current Drug Delivery Delivery of Neurotherapeutics Across the Blood Brain Barrier in Stroke
Current Pharmaceutical Design The Potential for Genetically Altered Microglia to Influence Glioma Treatment
CNS & Neurological Disorders - Drug Targets