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Abstract
CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.
Keywords: HIV, Entry, Co-receptor, CCR5, Small-molecule inhibitor, Maraviroc
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV
Volume: 10 Issue: 13
Author(s): Tao Liu, Zhiyong Weng, Xiaowu Dong and Yongzhou Hu
Affiliation:
Keywords: HIV, Entry, Co-receptor, CCR5, Small-molecule inhibitor, Maraviroc
Abstract: CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.
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Cite this article as:
Liu Tao, Weng Zhiyong, Dong Xiaowu and Hu Yongzhou, Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV, Mini-Reviews in Medicinal Chemistry 2010; 10 (13) . https://dx.doi.org/10.2174/13895575110091277
DOI https://dx.doi.org/10.2174/13895575110091277 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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