Abstract
The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.
Keywords: DNA and RNA binding, bis-intercalation, macrocyclic bis-intercalation, intercalator, nucleobase conjugate
Mini-Reviews in Medicinal Chemistry
Title: Recognition of Single Stranded and Double Stranded DNA/RNA Sequences in Aqueous Medium by Small Bis-Aromatic Derivatives
Volume: 10 Issue: 4
Author(s): L.-M. Tumir and I. Piantanida
Affiliation:
Keywords: DNA and RNA binding, bis-intercalation, macrocyclic bis-intercalation, intercalator, nucleobase conjugate
Abstract: The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.
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Cite this article as:
Tumir L.-M. and Piantanida I., Recognition of Single Stranded and Double Stranded DNA/RNA Sequences in Aqueous Medium by Small Bis-Aromatic Derivatives, Mini-Reviews in Medicinal Chemistry 2010; 10 (4) . https://dx.doi.org/10.2174/138955710791330990
DOI https://dx.doi.org/10.2174/138955710791330990 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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