![conference banner](/images/conference-banner.jpeg)
Abstract
Incorporation of nonnatural amino acids into proteins has exerted great effects on many fields. In recent years, the engineering of translation apparatus facilitates the boom of this field. The modifications on tRNAs, tRNA synthetases, ribosomes, elongation factors and release factors efficiently broaden the repertoire of amino acids and largely increase the efficiency of incorporation. In addition, deep understanding of the translation mechanism helps us generate certain kinds of RNAs which can act as alternative translation components to catalyze the aminoacylation step or inhibitors to attenuate the activity of a certain component. Here I review the strategies to evolve or engineer the components of translation apparatus as well as the methods to control their activity to meet our needs.
Keywords: Translation apparatus, nonnatural amino acids, trna, tRNA synthetase, aminoacylating ribozyme, ribosome, elongation factor, release factor
Current Protein & Peptide Science
Title: Engineering the Translation Apparatus to Incorporate Nonnatural Amino Acids
Volume: 11 Issue: 4
Author(s): Yang Qi
Affiliation:
Keywords: Translation apparatus, nonnatural amino acids, trna, tRNA synthetase, aminoacylating ribozyme, ribosome, elongation factor, release factor
Abstract: Incorporation of nonnatural amino acids into proteins has exerted great effects on many fields. In recent years, the engineering of translation apparatus facilitates the boom of this field. The modifications on tRNAs, tRNA synthetases, ribosomes, elongation factors and release factors efficiently broaden the repertoire of amino acids and largely increase the efficiency of incorporation. In addition, deep understanding of the translation mechanism helps us generate certain kinds of RNAs which can act as alternative translation components to catalyze the aminoacylation step or inhibitors to attenuate the activity of a certain component. Here I review the strategies to evolve or engineer the components of translation apparatus as well as the methods to control their activity to meet our needs.
Export Options
About this article
Cite this article as:
Qi Yang, Engineering the Translation Apparatus to Incorporate Nonnatural Amino Acids, Current Protein & Peptide Science 2010; 11 (4) . https://dx.doi.org/10.2174/138920310791233350
DOI https://dx.doi.org/10.2174/138920310791233350 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein/protein and RNA/protein interactions are essential for molecular regulations
Protein-protein and RNA-protein interactions are fundamental to the intricate regulatory mechanisms that govern various cellular processes, playing a crucial role in maintaining the delicate balance and coordination within the complex molecular landscape. Proteins, the workhorses of the cell, engage in a myriad of interactions, both with other proteins and with ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers