Abstract
Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.
Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation
Mini-Reviews in Medicinal Chemistry
Title: Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research
Volume: 9 Issue: 10
Author(s): Pauline F. Marx, Chantal J.N. Verkleij, Mercedes Valls Seron and Joost C.M. Meijers
Affiliation:
Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation
Abstract: Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.
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Cite this article as:
Marx F. Pauline, Verkleij J.N. Chantal, Seron Valls Mercedes and Meijers C.M. Joost, Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research, Mini-Reviews in Medicinal Chemistry 2009; 9 (10) . https://dx.doi.org/10.2174/138955709789055216
DOI https://dx.doi.org/10.2174/138955709789055216 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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