Abstract
Pulmonary fibrosis is involved in several respiratory diseases such as idiopathic interstitial pneumonias, druginduced pulmonary disease, occupational or environmental pulmonary disease and collagen vascular disease, and leads to systemic fatal damage in some cases. Several cytokines, inflammatory mediators, and growth factors play a complicated role in the progression of fibrosis, resulting in difficulty in specific therapy to overcome the disease. Among those mediators, inducible cyclooxygenase (COX)-2-dependent prostaglandin (PG) E2 exhibits inhibitory effects for fibroblast proliferation and collagen synthesis. Induction of COX-2 expression associated with increased production of PGE2 was observed in bleomycin-induced pulmonary fibrosis in rat. The inhibitory effects could be mediated via the EP2 and/or EP4 receptors coupled to elevation of cAMP. Fifteen-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2), which is a derivative of PGD2 by non-enzymatic hydrolysis and an anti-inflammatory PPAR γ ligand, has been focused in asthma, chronic obstructive pulmonary disease, acute lung injury and pulmonary fibrosis. Attenuation of pulmonary fibrosis by 15d-PGJ2 has confirmed by introduction of cells retrovirally transfected with PGD2 synthase cDNA. Administration of PGD2 synthaseexpressing cells to mice suppressed the fibrosis with reduced expression of fibrogenic growth factors. Thus, manipulation of anti-fibrogenic prostaglandins, PGE2 and 15d-PGJ2 may contribute to the development of specific therapy for pulmonary fibrosis.
Keywords: Pulmonary fibrosis, interstitial pneumonia, prostaglandin E2, 15-deoxy-Δ12,14-prostaglandin J2, prostaglandin D2 synthase, PPAR γ
Current Respiratory Medicine Reviews
Title: Role of Prostaglandin (PG) and Peroxisome Proliferator-Activated Gamma (PPAR γ ) in Pulmonary Fibrosis
Volume: 5 Issue: 1
Author(s): Izumi Hayashi, Hirahito Endo, Masato Katagiri and Hidero Kitasato
Affiliation:
Keywords: Pulmonary fibrosis, interstitial pneumonia, prostaglandin E2, 15-deoxy-Δ12,14-prostaglandin J2, prostaglandin D2 synthase, PPAR γ
Abstract: Pulmonary fibrosis is involved in several respiratory diseases such as idiopathic interstitial pneumonias, druginduced pulmonary disease, occupational or environmental pulmonary disease and collagen vascular disease, and leads to systemic fatal damage in some cases. Several cytokines, inflammatory mediators, and growth factors play a complicated role in the progression of fibrosis, resulting in difficulty in specific therapy to overcome the disease. Among those mediators, inducible cyclooxygenase (COX)-2-dependent prostaglandin (PG) E2 exhibits inhibitory effects for fibroblast proliferation and collagen synthesis. Induction of COX-2 expression associated with increased production of PGE2 was observed in bleomycin-induced pulmonary fibrosis in rat. The inhibitory effects could be mediated via the EP2 and/or EP4 receptors coupled to elevation of cAMP. Fifteen-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2), which is a derivative of PGD2 by non-enzymatic hydrolysis and an anti-inflammatory PPAR γ ligand, has been focused in asthma, chronic obstructive pulmonary disease, acute lung injury and pulmonary fibrosis. Attenuation of pulmonary fibrosis by 15d-PGJ2 has confirmed by introduction of cells retrovirally transfected with PGD2 synthase cDNA. Administration of PGD2 synthaseexpressing cells to mice suppressed the fibrosis with reduced expression of fibrogenic growth factors. Thus, manipulation of anti-fibrogenic prostaglandins, PGE2 and 15d-PGJ2 may contribute to the development of specific therapy for pulmonary fibrosis.
Export Options
About this article
Cite this article as:
Hayashi Izumi, Endo Hirahito, Katagiri Masato and Kitasato Hidero, Role of Prostaglandin (PG) and Peroxisome Proliferator-Activated Gamma (PPAR γ ) in Pulmonary Fibrosis, Current Respiratory Medicine Reviews 2009; 5 (1) . https://dx.doi.org/10.2174/157339809787354074
DOI https://dx.doi.org/10.2174/157339809787354074 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases
Mini-Reviews in Medicinal Chemistry Genetic Polymorphisms in Sigma-1 Receptor and Apolipoprotein E Interact to Influence the Severity of Alzheimers Disease
Current Alzheimer Research Statins as Antihypertensives
Recent Patents on Cardiovascular Drug Discovery Risk Stratification of Dyslipidemia: Insights from the Framingham Study
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Vitamin D and Stroke: Promise for Prevention and Better Outcome
Current Vascular Pharmacology Muramyl Dipeptide and its Derivatives: Peptide Adjuvant in Immunological Disorders and Cancer Therapy
Current Bioactive Compounds Matrix Metalloproteinases; A Biomarker of Disease Activity and Prognosis in Spondyloarthritis: A Narrative Review
Current Reviews in Clinical and Experimental Pharmacology Limited Hypotensive Effect of Sildenafil in a High-Risk Population: A Preliminary Report
Current Drug Safety Multiomics Investigation of Hypertension and White Matter Hyperintensity as a Source of Vascular Dementia or a Comorbidity to Alzheimer’s Disease
Current Alzheimer Research Targeting the Role of Astrocytes in the Progression of Alzheimers Disease
Current Signal Transduction Therapy Effect of Homocysteinylation on Structure, Chaperone Activity and Fibrillation Propensity of Lens Alpha-crystallin
Protein & Peptide Letters Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis
Current Topics in Medicinal Chemistry Review on <i>In-vitro</i> Techniques and <i>In-vivo</i> Animals Models for Screening Diabetes and Diabetic Complications
Current Diabetes Reviews Hypoxia-inducible Factor (HIF) in Hormone Signaling During Health and Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Coagulopathy in Type 2 Diabetes Mellitus: Pathological Mechanisms and the Role of Factor XIII-A Single Nucleotide Polymorphisms
Current Diabetes Reviews Consequences of Secondary Hyperparathyroidism on Vascular Calcification and Cardiovascular Mortality: Potential Benefit of Calcimimetics
Current Drug Therapy Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Current Pharmaceutical Design Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors
Current Drug Targets The Clinical Neuroscience of Post Stroke Depression
Current Neuropharmacology Cross-Talk Between Adipose Tissue Health, Myocardial Metabolism and Vascular Function: The Adipose-Myocardial and Adipose-Vascular Axes
Current Pharmaceutical Design