Abstract
Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.
Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies
Protein & Peptide Letters
Title: Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom
Volume: 15 Issue: 9
Author(s): Mario T. Murakami, Marco R. Lourenzoni, Emerson Z. Arruda, Marcelo A. Tomaz, Magno M. Vicoti, Jose R. B. Abrego, Paulo A. Melo and Raghuvir K. Arni
Affiliation:
Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies
Abstract: Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.
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Cite this article as:
Murakami T. Mario, Lourenzoni R. Marco, Arruda Z. Emerson, Tomaz A. Marcelo, Vicoti M. Magno, Abrego R. B. Jose, Melo A. Paulo and Arni K. Raghuvir, Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom, Protein & Peptide Letters 2008; 15 (9) . https://dx.doi.org/10.2174/092986608785849245
DOI https://dx.doi.org/10.2174/092986608785849245 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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