Abstract
Biodegradable polymeric scaffolds are widely used as a temporary extracellular matrix in tissue engineering and regenerative medicine. By physical adsorption of biomolecules on scaffold surface, physical entrapment of biomolecules in polymer microspheres or hydrogels, and chemical immobilization of oligopeptides or proteins on biomaterials, biologically active biomaterials and scaffolds can be derived. These bioactive systems show great potential in tissue engineering in rendering bioactivity and/or specificity to scaffolds. This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems.
Keywords: Chitosan, bioactive, biomolecules, scaffolds, surface modification, tissue engineering, regenerative medicine
Current Topics in Medicinal Chemistry
Title: Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine
Volume: 8 Issue: 4
Author(s): Cato T. Laurencin, Tao Jiang, Sangamesh G. Kumbar and Lakshmi S. Nair
Affiliation:
Keywords: Chitosan, bioactive, biomolecules, scaffolds, surface modification, tissue engineering, regenerative medicine
Abstract: Biodegradable polymeric scaffolds are widely used as a temporary extracellular matrix in tissue engineering and regenerative medicine. By physical adsorption of biomolecules on scaffold surface, physical entrapment of biomolecules in polymer microspheres or hydrogels, and chemical immobilization of oligopeptides or proteins on biomaterials, biologically active biomaterials and scaffolds can be derived. These bioactive systems show great potential in tissue engineering in rendering bioactivity and/or specificity to scaffolds. This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems.
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Cite this article as:
Laurencin T. Cato, Jiang Tao, Kumbar G. Sangamesh and Nair S. Lakshmi, Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine, Current Topics in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/156802608783790974
DOI https://dx.doi.org/10.2174/156802608783790974 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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