Abstract
Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.
Keywords: Opioid Receptor Like-1 (ORL-1), Nociceptin (orphanin FQ), Dynorphin A
Mini-Reviews in Medicinal Chemistry
Title: Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)
Volume: 1 Issue: 4
Author(s): D. Barlocco, L. Toma and G. Cignarella
Affiliation:
Keywords: Opioid Receptor Like-1 (ORL-1), Nociceptin (orphanin FQ), Dynorphin A
Abstract: Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.
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Cite this article as:
Barlocco D., Toma L. and Cignarella G., Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1), Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406657
DOI https://dx.doi.org/10.2174/1389557013406657 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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